myeloid hyperplasia_Gfi1<tm5.1(GFI1*)Tmo>/Gfi1<tm5.1(GFI1*)Tmo>,Kras<tm4Tyj>/Kras<+>,Tg(Mx1-cre)1Cgn/0

http://metadb.riken.jp/0010373I129S1Sv129S4SvJae129X1SvJC57BL6CBAGfi1tm51GFI1TmoGfi1tm51GFI1TmoKrastm4TyjKrasTgMx1cre1Cgn0KrasKrastm4TyjGfi1tm51GFI1TmoTgMx1cre1Cgn

myeloid hyperplasia_Gfi1<tm5.1(GFI1*)Tmo>/Gfi1<tm5.1(GFI1*)Tmo>,Kras<tm4Tyj>/Kras<+>,Tg(Mx1-cre)1Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072
• growth factor independent 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:103170

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gfi1<tm5.1(GFI1*)Tmo>/Gfi1<tm5.1(GFI1*)Tmo>,Kras<tm4Tyj>/Kras<+>,Tg(Mx1-cre)1Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kras<+>|Kras<tm4Tyj>|Gfi1<tm5.1(GFI1*)Tmo>|Tg(Mx1-cre)1Cgn

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• myeloid hyperplasia
  http://purl.obolibrary.org/obo/MP_0010373

文献

http://purl.org/net/cito/citesAsAuthority

• Cyrus. Khandanpour, et.al., The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice., Blood, 2012, 120
  http://rdf.ncbi.nlm.nih.gov/pubmed/22932805