altered tumor pathology_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0,Trp53<tm2Tyj>/Trp53<tm2Tyj>

http://metadb.riken.jp/0010639I129S4SvJae129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Trp53tm2TyjTrp53tm2TyjBraftm11BrdBrafTrp53tm2TyjTgVil1cre997Gum

altered tumor pathology_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0,Trp53<tm2Tyj>/Trp53<tm2Tyj>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion 997, Deborah L Gumucio
  http://metadb.riken.jp/db/mgi_rdf/MGI:2446957
• Braf transforming gene
  http://metadb.riken.jp/db/mgi_rdf/MGI:88190

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0,Trp53<tm2Tyj>/Trp53<tm2Tyj>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Braf<tm1.1Brd>|Braf<+>|Trp53<tm2Tyj>|Tg(Vil1-cre)997Gum

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• altered tumor pathology
  http://purl.obolibrary.org/obo/MP_0010639

文献

http://purl.org/net/cito/citesAsAuthority

• Roland. Rad, et.al., A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention., Cancer cell, 2013, 24
  http://rdf.ncbi.nlm.nih.gov/pubmed/23845441