Roland. Rad, et.al., A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention., Cancer cell, 2013, 24

http://rdf.ncbi.nlm.nih.gov/pubmed/23845441

Roland. Rad, et.al., A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention., Cancer cell, 2013, 24

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Braf<tm1.1Brd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5527388

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• branched small intestinal villi_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0014081I129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Braftm11BrdTgVil1cre997GumBraf
• increased intestinal adenoma incidence_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0002404I129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Braftm11BrdTgVil1cre997GumBraf
• increased intestinal adenoma incidence_Braf<tm1.1Brd>/Braf<+>,Cdkn2a<tm1.1Brn>/Cdkn2a<tm1.1Brn>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0002404I129P2OlaHsd129S7SvEvBrdC57BL6SJLBraftm11BrdBrafCdkn2atm11BrnCdkn2atm11BrnTgVil1cre997Gum0BrafTgVil1cre997GumBraftm11BrdCdkn2atm11Brn
• abnormal intestinal mucosa morphology_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0000511I129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Braftm11BrdTgVil1cre997GumBraf
• increased carcinoma incidence_Braf<tm1.1Brd>/Braf<+>,Cdkn2a<tm1.1Brn>/Cdkn2a<tm1.1Brn>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0002038I129P2OlaHsd129S7SvEvBrdC57BL6SJLBraftm11BrdBrafCdkn2atm11BrnCdkn2atm11BrnTgVil1cre997Gum0BrafTgVil1cre997GumBraftm11BrdCdkn2atm11Brn
• abnormal small intestinal villus morphology_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0008108I129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Braftm11BrdTgVil1cre997GumBraf
• abnormal large intestine crypts of Lieberkuhn morphology_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0004842I129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Braftm11BrdTgVil1cre997GumBraf
• increased gastrointestinal tumor incidence_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0010279I129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Braftm11BrdTgVil1cre997GumBraf
• abnormal intestinal epithelium morphology_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0000488I129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Braftm11BrdTgVil1cre997GumBraf
• altered tumor pathology_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0,Trp53<tm2Tyj>/Trp53<tm2Tyj>
  http://metadb.riken.jp/0010639I129S4SvJae129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Trp53tm2TyjTrp53tm2TyjBraftm11BrdBrafTrp53tm2TyjTgVil1cre997Gum
• increased small intestine length_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0013957I129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Braftm11BrdTgVil1cre997GumBraf
• increased carcinoma incidence_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0002038I129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Braftm11BrdTgVil1cre997GumBraf
• abnormal crypts of Lieberkuhn morphology_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0000490I129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Braftm11BrdTgVil1cre997GumBraf
• increased metastatic potential_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0,Trp53<tm2Tyj>/Trp53<tm2Tyj>
  http://metadb.riken.jp/0001272I129S4SvJae129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Trp53tm2TyjTrp53tm2TyjBraftm11BrdBrafTrp53tm2TyjTgVil1cre997Gum
• abnormal small intestine morphology_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0000496I129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Braftm11BrdTgVil1cre997GumBraf
• intestine polyps_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0008011I129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Braftm11BrdTgVil1cre997GumBraf
• abnormal large intestine morphology_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0000489I129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Braftm11BrdTgVil1cre997GumBraf
• increased large intestine length_Braf<tm1.1Brd>/Braf<+>,Tg(Vil1-cre)997Gum/0
  http://metadb.riken.jp/0013959I129S7SvEvBrdC57BL6SJLBraftm11BrdBrafTgVil1cre997Gum0Braftm11BrdTgVil1cre997GumBraf

class

http://purl.org/net/cito/citesAsAuthority

• Braf<tm1.1Brd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5527388