increased aorta wall thickness_Agtr1a<tm1Unc>/Agtr1a<tm1Unc>,Efemp2<tm1.1Hiya>/Efemp2<tm1.2Hiya>,Tg(Tagln-cre)1Her/0

http://metadb.riken.jp/0010996I129P2OlaHsd129S6SvEvTacC57BL6SJLAgtr1atm1UncAgtr1atm1UncEfemp2tm11HiyaEfemp2tm12HiyaTgTaglncre1Her0TgTaglncre1HerEfemp2tm12HiyaAgtr1atm1UncEfemp2tm11Hiya

increased aorta wall thickness_Agtr1a<tm1Unc>/Agtr1a<tm1Unc>,Efemp2<tm1.1Hiya>/Efemp2<tm1.2Hiya>,Tg(Tagln-cre)1Her/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• angiotensin II receptor, type 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:87964
• transgene insertion 1, Joachim Herz
  http://metadb.riken.jp/db/mgi_rdf/MGI:2450259
• epidermal growth factor-containing fibulin-like extracellular matrix protein 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:1891209

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Agtr1a<tm1Unc>/Agtr1a<tm1Unc>,Efemp2<tm1.1Hiya>/Efemp2<tm1.2Hiya>,Tg(Tagln-cre)1Her/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Tagln-cre)1Her|Efemp2<tm1.2Hiya>|Agtr1a<tm1Unc>|Efemp2<tm1.1Hiya>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased aorta wall thickness
  http://purl.obolibrary.org/obo/MP_0010996

文献

http://purl.org/net/cito/citesAsAuthority

• Jianbin. Huang, et.al., Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice., Science translational medicine, 2013, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/23636094