impaired adaptive thermogenesis_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?

http://metadb.riken.jp/0011049I129SvC57BL6DBA2Thratm1FflaThraTgSycp1cre4MinThratm1FflaThraTgSycp1cre4Min

impaired adaptive thermogenesis_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 4, Minoo Rassoulzadegan
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176062
• thyroid hormone receptor alpha
  http://metadb.riken.jp/db/mgi_rdf/MGI:98742

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Thra<tm1Ffla>|Thra<+>|Tg(Sycp1-cre)4Min

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• impaired adaptive thermogenesis
  http://purl.obolibrary.org/obo/MP_0011049

文献

http://purl.org/net/cito/citesAsAuthority

• Laure. Quignodon, et.al., A point mutation in the activation function 2 domain of thyroid hormone receptor alpha1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism., Molecular endocrinology (Baltimore, Md.), 2007, 21
  http://rdf.ncbi.nlm.nih.gov/pubmed/17622582