Laure. Quignodon, et.al., A point mutation in the activation function 2 domain of thyroid hormone receptor alpha1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism., Molecular endocrinology (Baltimore, Md.), 2007, 21

http://rdf.ncbi.nlm.nih.gov/pubmed/17622582

Laure. Quignodon, et.al., A point mutation in the activation function 2 domain of thyroid hormone receptor alpha1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism., Molecular endocrinology (Baltimore, Md.), 2007, 21

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Thra<tm1Ffla>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3758914

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• delayed eyelid opening_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?
  http://metadb.riken.jp/0001290I129SvC57BL6DBA2Thratm1FflaThraTgSycp1cre4MinThratm1FflaThraTgSycp1cre4Min
• abnormal Purkinje cell dendrite morphology_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?
  http://metadb.riken.jp/0008572I129SvC57BL6DBA2Thratm1FflaThraTgSycp1cre4MinThratm1FflaThraTgSycp1cre4Min
• disproportionate dwarf_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?
  http://metadb.riken.jp/0002427I129SvC57BL6DBA2Thratm1FflaThraTgSycp1cre4MinThratm1FflaThraTgSycp1cre4Min
• decreased spleen weight_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?
  http://metadb.riken.jp/0004953I129SvC57BL6DBA2Thratm1FflaThraTgSycp1cre4MinThratm1FflaThraTgSycp1cre4Min
• postnatal growth retardation_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?
  http://metadb.riken.jp/0001732I129SvC57BL6DBA2Thratm1FflaThraTgSycp1cre4MinThratm1FflaThraTgSycp1cre4Min
• abnormal cerebellum morphology_Tg(CAG-cre/Esr1*)5Amc/?,Thra<tm1Ffla>/Thra<+>
  http://metadb.riken.jp/0000849I129SvC57BL6CBATgCAGcreEsr15AmcThratm1FflaThraTgCAGcreEsr15AmcThraThratm1Ffla
• delayed endochondral bone ossification_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?
  http://metadb.riken.jp/0003419I129SvC57BL6DBA2Thratm1FflaThraTgSycp1cre4MinThratm1FflaThraTgSycp1cre4Min
• abnormal postnatal growth_Tg(CAG-cre/Esr1*)5Amc/?,Thra<tm1Ffla>/Thra<+>
  http://metadb.riken.jp/0001731I129SvC57BL6CBATgCAGcreEsr15AmcThratm1FflaThraTgCAGcreEsr15AmcThraThratm1Ffla
• postnatal lethality, incomplete penetrance_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?
  http://metadb.riken.jp/0011086I129SvC57BL6DBA2Thratm1FflaThraTgSycp1cre4MinThratm1FflaThraTgSycp1cre4Min
• female infertility_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?
  http://metadb.riken.jp/0001926I129SvC57BL6DBA2Thratm1FflaThraTgSycp1cre4MinThratm1FflaThraTgSycp1cre4Min
• irregular heartbeat_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?
  http://metadb.riken.jp/0001636I129SvC57BL6DBA2Thratm1FflaThraTgSycp1cre4MinThratm1FflaThraTgSycp1cre4Min
• abnormal heart rate_Tg(CAG-cre/Esr1*)5Amc/?,Thra<tm1Ffla>/Thra<+>
  http://metadb.riken.jp/0001629I129SvC57BL6CBATgCAGcreEsr15AmcThratm1FflaThraTgCAGcreEsr15AmcThraThratm1Ffla
• impaired adaptive thermogenesis_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?
  http://metadb.riken.jp/0011049I129SvC57BL6DBA2Thratm1FflaThraTgSycp1cre4MinThratm1FflaThraTgSycp1cre4Min
• abnormal cerebellum external granule cell layer morphology_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?
  http://metadb.riken.jp/0000872I129SvC57BL6DBA2Thratm1FflaThraTgSycp1cre4MinThratm1FflaThraTgSycp1cre4Min
• increased heart rate_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?
  http://metadb.riken.jp/0002626I129SvC57BL6DBA2Thratm1FflaThraTgSycp1cre4MinThratm1FflaThraTgSycp1cre4Min
• ataxia_Thra<tm1Ffla>/Thra<+>,Tg(Sycp1-cre)4Min/?
  http://metadb.riken.jp/0001393I129SvC57BL6DBA2Thratm1FflaThraTgSycp1cre4MinThratm1FflaThraTgSycp1cre4Min
• delayed bone ossification_Tg(CAG-cre/Esr1*)5Amc/?,Thra<tm1Ffla>/Thra<+>
  http://metadb.riken.jp/0000060I129SvC57BL6CBATgCAGcreEsr15AmcThratm1FflaThraTgCAGcreEsr15AmcThraThratm1Ffla

class

http://purl.org/net/cito/citesAsAuthority

• Thra<tm1Ffla>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3758914