postnatal lethality, complete penetrance_Vps18<tm1.1Wtao>/Vps18<tm1.1Wtao>,Tg(Nes-cre)1Kln/0

http://metadb.riken.jp/0011085I129S4SvJaeSor129S6SvEvTacC57BL6SJLVps18tm11WtaoVps18tm11WtaoTgNescre1Kln0Vps18tm11WtaoTgNescre1Kln

postnatal lethality, complete penetrance_Vps18<tm1.1Wtao>/Vps18<tm1.1Wtao>,Tg(Nes-cre)1Kln/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• VPS18 CORVET/HOPS core subunit
  http://metadb.riken.jp/db/mgi_rdf/MGI:2443626
• transgene insertion 1, Rudiger Klein
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176172

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Vps18<tm1.1Wtao>/Vps18<tm1.1Wtao>,Tg(Nes-cre)1Kln/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Vps18<tm1.1Wtao>|Tg(Nes-cre)1Kln

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete postnatal lethality
  http://purl.obolibrary.org/obo/MP_0011085

文献

http://purl.org/net/cito/citesAsAuthority

• Chao. Peng, et.al., Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes., The Journal of biological chemistry, 2012, 287
  http://rdf.ncbi.nlm.nih.gov/pubmed/22854957