postnatal lethality, complete penetrance_Atg5<tm1Myok>/Atg5<tm1Myok>,Rheb<tm1.1Otsu>/Rheb<tm1.1Otsu>,Tg(Myh6-cre)2182Mds/0

http://metadb.riken.jp/0011085I129SSvEvC57BL6JFVBNAtg5tm1MyokAtg5tm1MyokRhebtm11OtsuRhebtm11OtsuTgMyh6cre2182Mds0TgMyh6cre2182MdsRhebtm11OtsuAtg5tm1Myok

postnatal lethality, complete penetrance_Atg5<tm1Myok>/Atg5<tm1Myok>,Rheb<tm1.1Otsu>/Rheb<tm1.1Otsu>,Tg(Myh6-cre)2182Mds/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Ras homolog enriched in brain
  http://metadb.riken.jp/db/mgi_rdf/MGI:97912
• autophagy related 5
  http://metadb.riken.jp/db/mgi_rdf/MGI:1277186
• transgene insertion 2182, Michael D Schneider
  http://metadb.riken.jp/db/mgi_rdf/MGI:2447636

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Atg5<tm1Myok>/Atg5<tm1Myok>,Rheb<tm1.1Otsu>/Rheb<tm1.1Otsu>,Tg(Myh6-cre)2182Mds/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Myh6-cre)2182Mds|Rheb<tm1.1Otsu>|Atg5<tm1Myok>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S/SvEv * C57BL/6J * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete postnatal lethality
  http://purl.obolibrary.org/obo/MP_0011085

文献

http://purl.org/net/cito/citesAsAuthority

• Takahito. Tamai, et.al., Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period., The Journal of biological chemistry, 2013, 288
  http://rdf.ncbi.nlm.nih.gov/pubmed/23426372