Takahito. Tamai, et.al., Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period., The Journal of biological chemistry, 2013, 288

http://rdf.ncbi.nlm.nih.gov/pubmed/23426372

Takahito. Tamai, et.al., Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period., The Journal of biological chemistry, 2013, 288

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Rheb<tm1.1Otsu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5502740

class

http://purl.org/net/cito/citesAsAuthority

• Rheb<tm1.1Otsu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5502740

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal sarcomere morphology_Rheb<tm1.1Otsu>/Rheb<tm1.1Otsu>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0004090I129C57BL6JFVBNRhebtm11OtsuRhebtm11OtsuTgMyh6cre2182Mds0Rhebtm11OtsuTgMyh6cre2182Mds
• cardiomyopathy_Rheb<tm1.1Otsu>/Rheb<tm1.1Otsu>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005330I129C57BL6JFVBNRhebtm11OtsuRhebtm11OtsuTgMyh6cre2182Mds0Rhebtm11OtsuTgMyh6cre2182Mds
• no abnormal phenotype detected_Rheb<tm1.1Otsu>/Rheb<tm1.1Otsu>
  http://metadb.riken.jp/0002169I129C57BL6JRhebtm11OtsuRhebtm11OtsuRhebtm11Otsu
• postnatal lethality, complete penetrance_Rheb<tm1.1Otsu>/Rheb<tm1.1Otsu>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0011085I129C57BL6JFVBNRhebtm11OtsuRhebtm11OtsuTgMyh6cre2182Mds0Rhebtm11OtsuTgMyh6cre2182Mds
• abnormal heart left ventricle morphology_Rheb<tm1.1Otsu>/Rheb<tm1.1Otsu>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0003921I129C57BL6JFVBNRhebtm11OtsuRhebtm11OtsuTgMyh6cre2182Mds0Rhebtm11OtsuTgMyh6cre2182Mds
• thin interventricular septum_Rheb<tm1.1Otsu>/Rheb<tm1.1Otsu>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0010725I129C57BL6JFVBNRhebtm11OtsuRhebtm11OtsuTgMyh6cre2182Mds0Rhebtm11OtsuTgMyh6cre2182Mds
• decreased cardiac muscle contractility_Rheb<tm1.1Otsu>/Rheb<tm1.1Otsu>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0005140I129C57BL6JFVBNRhebtm11OtsuRhebtm11OtsuTgMyh6cre2182Mds0Rhebtm11OtsuTgMyh6cre2182Mds
• decreased heart weight_Rheb<tm1.1Otsu>/Rheb<tm1.1Otsu>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0002834I129C57BL6JFVBNRhebtm11OtsuRhebtm11OtsuTgMyh6cre2182Mds0Rhebtm11OtsuTgMyh6cre2182Mds
• small myocardial fiber_Rheb<tm1.1Otsu>/Rheb<tm1.1Otsu>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0004565I129C57BL6JFVBNRhebtm11OtsuRhebtm11OtsuTgMyh6cre2182Mds0Rhebtm11OtsuTgMyh6cre2182Mds
• postnatal lethality, incomplete penetrance_Eif4ebp1<tm1Nso>/Eif4ebp1<tm1Nso>,Rheb<tm1.1Otsu>/Rheb<tm1.1Otsu>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0011086I129C57BL6JFVBNEif4ebp1tm1NsoEif4ebp1tm1NsoRhebtm11OtsuRhebtm11OtsuTgMyh6cre2182Mds0TgMyh6cre2182MdsEif4ebp1tm1NsoRhebtm11Otsu
• postnatal lethality, complete penetrance_Atg5<tm1Myok>/Atg5<tm1Myok>,Rheb<tm1.1Otsu>/Rheb<tm1.1Otsu>,Tg(Myh6-cre)2182Mds/0
  http://metadb.riken.jp/0011085I129SSvEvC57BL6JFVBNAtg5tm1MyokAtg5tm1MyokRhebtm11OtsuRhebtm11OtsuTgMyh6cre2182Mds0TgMyh6cre2182MdsRhebtm11OtsuAtg5tm1Myok