neonatal lethality, complete penetrance_Gt(ROSA)26Sor<tm1(Wnk1)Clhu>/Gt(ROSA)26Sor<+>,Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>,Tg(Tek-cre)12Flv/0

http://metadb.riken.jp/0011087I129S5SvEvBrdC3HC57BL6GtROSA26Sortm1Wnk1ClhuGtROSA26SorWnk1GtOST38262LexWnk1GtOST38262LexTgTekcre12Flv0GtROSA26SorWnk1GtOST38262LexTgTekcre12FlvGtROSA26Sortm1Wnk1Clhu

neonatal lethality, complete penetrance_Gt(ROSA)26Sor<tm1(Wnk1)Clhu>/Gt(ROSA)26Sor<+>,Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>,Tg(Tek-cre)12Flv/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• WNK lysine deficient protein kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:2442092
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 12, Richard A Flavell
  http://metadb.riken.jp/db/mgi_rdf/MGI:2136409

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(Wnk1)Clhu>/Gt(ROSA)26Sor<+>,Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>,Tg(Tek-cre)12Flv/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<+>|Wnk1<Gt(OST38262)Lex>|Tg(Tek-cre)12Flv|Gt(ROSA)26Sor<tm1(Wnk1)Clhu>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S5/SvEvBrd * C3H * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete neonatal lethality
  http://purl.obolibrary.org/obo/MP_0011087

文献

http://purl.org/net/cito/citesAsAuthority

• Jian. Xie, et.al., Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice., The American journal of pathology, 2009, 175
  http://rdf.ncbi.nlm.nih.gov/pubmed/19644017