Jian. Xie, et.al., Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice., The American journal of pathology, 2009, 175

http://rdf.ncbi.nlm.nih.gov/pubmed/19644017

Jian. Xie, et.al., Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice., The American journal of pathology, 2009, 175

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Wnk1<tm1Clhu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4360972
• Gt(ROSA)26Sor<tm1(Wnk1)Clhu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4360975

class

http://purl.org/net/cito/citesAsAuthority

• Wnk1<tm1Clhu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4360972
• Gt(ROSA)26Sor<tm1(Wnk1)Clhu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4360975

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal vascular branching morphogenesis_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0003227I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• decreased embryo size_Wnk1<tm1Clhu>/Wnk1<tm1Clhu>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0001698IC3HC57BL6Wnk1tm1ClhuWnk1tm1ClhuTgTekcre12Flv0TgTekcre12FlvWnk1tm1Clhu
• thin myocardium_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0002652I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• abnormal myocardial trabeculae morphology_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0002189I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• abnormal cardinal vein morphology_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0004783I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• embryonic lethality during organogenesis, complete penetrance_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0011098I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• abnormal cardinal vein morphology_Wnk1<tm1Clhu>/Wnk1<tm1Clhu>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0004783IC3HC57BL6Wnk1tm1ClhuWnk1tm1ClhuTgTekcre12Flv0TgTekcre12FlvWnk1tm1Clhu
• abnormal brain vasculature morphology_Wnk1<tm1Clhu>/Wnk1<tm1Clhu>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0004950IC3HC57BL6Wnk1tm1ClhuWnk1tm1ClhuTgTekcre12Flv0TgTekcre12FlvWnk1tm1Clhu
• abnormal dorsal aorta morphology_Wnk1<tm1Clhu>/Wnk1<tm1Clhu>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0004787IC3HC57BL6Wnk1tm1ClhuWnk1tm1ClhuTgTekcre12Flv0TgTekcre12FlvWnk1tm1Clhu
• abnormal vitelline vascular remodeling_Wnk1<tm1Clhu>/Wnk1<tm1Clhu>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0004076IC3HC57BL6Wnk1tm1ClhuWnk1tm1ClhuTgTekcre12Flv0TgTekcre12FlvWnk1tm1Clhu
• pericardial edema_Wnk1<tm1Clhu>/Wnk1<tm1Clhu>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0001787IC3HC57BL6Wnk1tm1ClhuWnk1tm1ClhuTgTekcre12Flv0TgTekcre12FlvWnk1tm1Clhu
• intracranial hemorrhage_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0001915I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• abnormal placental labyrinth vasculature morphology_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0008803I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• embryonic growth retardation_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0003984I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• heart hypoplasia_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0002740I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• pale yolk sac_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0001722I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• distended pericardium_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0000292I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• abnormal dorsal aorta morphology_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0004787I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• abnormal visceral yolk sac morphology_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0001718I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• neonatal lethality, complete penetrance_Gt(ROSA)26Sor<tm1(Wnk1)Clhu>/Gt(ROSA)26Sor<+>,Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0011087I129S5SvEvBrdC3HC57BL6GtROSA26Sortm1Wnk1ClhuGtROSA26SorWnk1GtOST38262LexWnk1GtOST38262LexTgTekcre12Flv0GtROSA26SorWnk1GtOST38262LexTgTekcre12FlvGtROSA26Sortm1Wnk1Clhu
• abnormal angiogenesis_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0000260I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• abnormal brain vasculature morphology_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0004950I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• abnormal vascular branching morphogenesis_Wnk1<tm1Clhu>/Wnk1<tm1Clhu>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0003227IC3HC57BL6Wnk1tm1ClhuWnk1tm1ClhuTgTekcre12Flv0TgTekcre12FlvWnk1tm1Clhu
• hemorrhage_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0001914I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• abnormal embryo development_Gt(ROSA)26Sor<tm1(Wnk1)Clhu>/Gt(ROSA)26Sor<+>,Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0001672I129S5SvEvBrdC3HC57BL6GtROSA26Sortm1Wnk1ClhuGtROSA26SorWnk1GtOST38262LexWnk1GtOST38262LexTgTekcre12Flv0GtROSA26SorWnk1GtOST38262LexTgTekcre12FlvGtROSA26Sortm1Wnk1Clhu
• abnormal vitelline vasculature morphology_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0003229I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• embryonic lethality during organogenesis, complete penetrance_Wnk1<tm1Clhu>/Wnk1<tm1Clhu>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0011098IC3HC57BL6Wnk1tm1ClhuWnk1tm1ClhuTgTekcre12Flv0TgTekcre12FlvWnk1tm1Clhu
• pericardial edema_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0001787I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• abnormal placenta labyrinth morphology_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0001716I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• heart hemorrhage_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0009698I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• abnormal blood vessel morphology_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0001614I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• trabecula carnea hypoplasia_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0000295I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• embryonic lethality during organogenesis_Gt(ROSA)26Sor<tm1(Wnk1)Clhu>/Gt(ROSA)26Sor<+>,Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>,Tg(Sox2-cre)1Amc/0
  http://metadb.riken.jp/0006207I129S5SvEvBrdC57BL6CBAGtROSA26Sortm1Wnk1ClhuGtROSA26SorWnk1GtOST38262LexWnk1GtOST38262LexTgSox2cre1Amc0TgSox2cre1AmcGtROSA26Sortm1Wnk1ClhuGtROSA26SorWnk1GtOST38262Lex
• abnormal myocardial trabeculae morphology_Wnk1<tm1Clhu>/Wnk1<tm1Clhu>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0002189IC3HC57BL6Wnk1tm1ClhuWnk1tm1ClhuTgTekcre12Flv0TgTekcre12FlvWnk1tm1Clhu
• abnormal embryo development_Gt(ROSA)26Sor<tm1(Wnk1)Clhu>/Gt(ROSA)26Sor<+>,Kdr<tm1(cre)Sato>/Kdr<+>,Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0001672I129S1Sv129S5SvEvBrdGtROSA26Sortm1Wnk1ClhuGtROSA26SorKdrtm1creSatoKdrWnk1GtOST38262LexWnk1GtOST38262LexKdrtm1creSatoGtROSA26Sortm1Wnk1ClhuWnk1GtOST38262LexGtROSA26SorKdr
• abnormal vitelline vasculature morphology_Wnk1<tm1Clhu>/Wnk1<tm1Clhu>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0003229IC3HC57BL6Wnk1tm1ClhuWnk1tm1ClhuTgTekcre12Flv0TgTekcre12FlvWnk1tm1Clhu
• internal hemorrhage_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0001634I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex
• thin myocardium_Wnk1<tm1Clhu>/Wnk1<tm1Clhu>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0002652IC3HC57BL6Wnk1tm1ClhuWnk1tm1ClhuTgTekcre12Flv0TgTekcre12FlvWnk1tm1Clhu
• heart hypoplasia_Wnk1<tm1Clhu>/Wnk1<tm1Clhu>,Tg(Tek-cre)12Flv/0
  http://metadb.riken.jp/0002740IC3HC57BL6Wnk1tm1ClhuWnk1tm1ClhuTgTekcre12Flv0TgTekcre12FlvWnk1tm1Clhu
• abnormal vitelline vascular remodeling_Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>
  http://metadb.riken.jp/0004076I129S5SvEvBrdWnk1GtOST38262LexWnk1GtOST38262LexWnk1GtOST38262Lex

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD27615
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD27615