neonatal lethality, complete penetrance_Epas1<tm1Pec>/Epas1<tm1Pec>

http://metadb.riken.jp/0011087I129SvSwissEpas1tm1PecEpas1tm1PecEpas1tm1Pec

neonatal lethality, complete penetrance_Epas1<tm1Pec>/Epas1<tm1Pec>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• endothelial PAS domain protein 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:109169

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Epas1<tm1Pec>/Epas1<tm1Pec>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Epas1<tm1Pec>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * Swiss

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete neonatal lethality
  http://purl.obolibrary.org/obo/MP_0011087

文献

http://purl.org/net/cito/citesAsAuthority

• Veerle. Compernolle, et.al., Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice., Nature medicine, 2002, 8
  http://rdf.ncbi.nlm.nih.gov/pubmed/12053176
• Koen. Brusselmans, et.al., Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia., The Journal of clinical investigation, 2003, 111
  http://rdf.ncbi.nlm.nih.gov/pubmed/12750401