perinatal lethality, complete penetrance_Porcn<tm1.1Lcm>/Porcn<+>,Tg(Sox2-cre)1Amc/0

http://metadb.riken.jp/0011089I129S1Sv129X1SvJC57BL6CBAPorcntm11LcmPorcnTgSox2cre1Amc0Porcntm11LcmPorcnTgSox2cre1Amc

perinatal lethality, complete penetrance_Porcn<tm1.1Lcm>/Porcn<+>,Tg(Sox2-cre)1Amc/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Andrew P McMahon
  http://metadb.riken.jp/db/mgi_rdf/MGI:2656537
• porcupine homolog (Drosophila)
  http://metadb.riken.jp/db/mgi_rdf/MGI:1890212

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Porcn<tm1.1Lcm>/Porcn<+>,Tg(Sox2-cre)1Amc/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Porcn<tm1.1Lcm>|Porcn<+>|Tg(Sox2-cre)1Amc

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete perinatal lethality
  http://purl.obolibrary.org/obo/MP_0011089

文献

http://purl.org/net/cito/citesAsAuthority

• Jared J. Barrott, et.al., Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21768372