prenatal lethality, complete penetrance_Mdm2<tm1Glo>/Mdm2<tm1Glo>,Trp53<tm3.1Glo>/Trp53<+>

http://metadb.riken.jp/0011091I129S7SvEvBrdC57BL6Mdm2tm1GloMdm2tm1GloTrp53tm31GloTrp53Mdm2tm1GloTrp53Trp53tm31Glo

prenatal lethality, complete penetrance_Mdm2<tm1Glo>/Mdm2<tm1Glo>,Trp53<tm3.1Glo>/Trp53<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformed mouse 3T3 cell double minute 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:96952
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mdm2<tm1Glo>/Mdm2<tm1Glo>,Trp53<tm3.1Glo>/Trp53<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mdm2<tm1Glo>|Trp53<+>|Trp53<tm3.1Glo>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete prenatal lethality
  http://purl.obolibrary.org/obo/MP_0011091

文献

http://purl.org/net/cito/citesAsAuthority

• Gene A. Lang, et.al., Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome., Cell, 2004, 119
  http://rdf.ncbi.nlm.nih.gov/pubmed/15607981