Gene A. Lang, et.al., Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome., Cell, 2004, 119

http://rdf.ncbi.nlm.nih.gov/pubmed/15607981

Gene A. Lang, et.al., Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome., Cell, 2004, 119

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Trp53<tm3Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3722177
• Trp53<tm3.1Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3528279

class

http://purl.org/net/cito/citesAsAuthority

• Trp53<tm3Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3722177
• Trp53<tm3.1Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3528279

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased lymphoma incidence_Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0012431B6129S7Trp53tm31GloTrp53tm31GloTrp53Trp53Trp53tm31Glo
• increased fibroblast proliferation_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0011703I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• abnormal cell cycle_Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0003077B6129S7Trp53tm31GloTrp53tm31GloTrp53Trp53Trp53tm31Glo
• decreased cellular sensitivity to gamma-irradiation_Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0003207B6129S7Trp53tm31GloTrp53tm31GloTrp53Trp53Trp53tm31Glo
• increased fibroblast proliferation_Trp53<tm3.1Glo>/Trp53<tm3.1Glo>
  http://metadb.riken.jp/0011703B6129S7Trp53tm31GloTrp53tm31GloTrp53tm31GloTrp53tm31Glo
• increased metastatic potential_Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0001272B6129S7Trp53tm31GloTrp53tm31GloTrp53Trp53Trp53tm31Glo
• increased carcinoma incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002038I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• premature death_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002083I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• premature death_Trp53<tm3.1Glo>/Trp53<tm3.1Glo>
  http://metadb.riken.jp/0002083B6129S7Trp53tm31GloTrp53tm31GloTrp53tm31GloTrp53tm31Glo
• increased sarcoma incidence_Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0002032B6129S7Trp53tm31GloTrp53tm31GloTrp53Trp53Trp53tm31Glo
• premature death_Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0002083B6129S7Trp53tm31GloTrp53tm31GloTrp53Trp53Trp53tm31Glo
• increased fibroblast proliferation_Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0011703B6129S7Trp53tm31GloTrp53tm31GloTrp53Trp53Trp53tm31Glo
• abnormal DNA replication_Trp53<tm3.1Glo>/Trp53<tm3.1Glo>
  http://metadb.riken.jp/0008057B6129S7Trp53tm31GloTrp53tm31GloTrp53tm31GloTrp53tm31Glo
• increased sarcoma incidence_Trp53<tm3.1Glo>/Trp53<tm3.1Glo>
  http://metadb.riken.jp/0002032B6129S7Trp53tm31GloTrp53tm31GloTrp53tm31GloTrp53tm31Glo
• increased lymphoma incidence_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0012431I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• premature death_Trp53<tm1Tyj>/Trp53<tm3.1Glo>
  http://metadb.riken.jp/0002083I129S2SvPas129S7SvEvBrdC57BL6Trp53tm1TyjTrp53tm31GloTrp53tm1TyjTrp53tm31Glo
• decreased cellular sensitivity to gamma-irradiation_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0003207I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• increased lymphoma incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0012431I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• premature death_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002083I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• increased sarcoma incidence_Trp53<tm1Tyj>/Trp53<+>
  http://metadb.riken.jp/0002032I129S2SvPasC57BL6Trp53tm1TyjTrp53Trp53Trp53tm1Tyj
• increased carcinoma incidence_Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0002038B6129S7Trp53tm31GloTrp53tm31GloTrp53Trp53Trp53tm31Glo
• increased sarcoma incidence_Trp53<tm1Tyj>/Trp53<tm1Tyj>
  http://metadb.riken.jp/0002032I129S2SvPasC57BL6Trp53tm1TyjTrp53tm1TyjTrp53tm1Tyj
• increased lymphoma incidence_Trp53<tm3.1Glo>/Trp53<tm3.1Glo>
  http://metadb.riken.jp/0012431B6129S7Trp53tm31GloTrp53tm31GloTrp53tm31GloTrp53tm31Glo
• prenatal lethality, complete penetrance_Mdm2<tm1Glo>/Mdm2<tm1Glo>,Trp53<tm3.1Glo>/Trp53<+>
  http://metadb.riken.jp/0011091I129S7SvEvBrdC57BL6Mdm2tm1GloMdm2tm1GloTrp53tm31GloTrp53Mdm2tm1GloTrp53Trp53tm31Glo