prenatal lethality, complete penetrance_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,Lig4<tm1Fwa>/Lig4<tm1Fwa>

http://metadb.riken.jp/0011091I129Sv129S6SvEvTacC57BL6JSJLCdkn2atm1RdpCdkn2atm1RdpLig4tm1FwaLig4tm1FwaLig4tm1FwaCdkn2atm1Rdp

prenatal lethality, complete penetrance_Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,Lig4<tm1Fwa>/Lig4<tm1Fwa>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cyclin-dependent kinase inhibitor 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:104738
• ligase IV, DNA, ATP-dependent
  http://metadb.riken.jp/db/mgi_rdf/MGI:1335098

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn2a<tm1Rdp>/Cdkn2a<tm1Rdp>,Lig4<tm1Fwa>/Lig4<tm1Fwa>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lig4<tm1Fwa>|Cdkn2a<tm1Rdp>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete prenatal lethality
  http://purl.obolibrary.org/obo/MP_0011091

文献

http://purl.org/net/cito/citesAsAuthority

• K M. Frank, et.al., DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway., Molecular cell, 2000, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/10911993