embryonic lethality, complete penetrance_Mdm2<tm1Glo>/Mdm2<tm1Glo>,Trp53<tm1Glo>/Trp53<tm1Glo>

http://metadb.riken.jp/0011092I129S7SvEvBrdC57BL6Mdm2tm1GloMdm2tm1GloTrp53tm1GloTrp53tm1GloMdm2tm1GloTrp53tm1Glo

embryonic lethality, complete penetrance_Mdm2<tm1Glo>/Mdm2<tm1Glo>,Trp53<tm1Glo>/Trp53<tm1Glo>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transformed mouse 3T3 cell double minute 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:96952
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mdm2<tm1Glo>/Mdm2<tm1Glo>,Trp53<tm1Glo>/Trp53<tm1Glo>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mdm2<tm1Glo>|Trp53<tm1Glo>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete embryonic lethality
  http://purl.obolibrary.org/obo/MP_0011092

文献

http://purl.org/net/cito/citesAsAuthority

• Yongxing. Wang, et.al., Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation., The Journal of clinical investigation, 2011, 121
  http://rdf.ncbi.nlm.nih.gov/pubmed/21285512