Yongxing. Wang, et.al., Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation., The Journal of clinical investigation, 2011, 121

http://rdf.ncbi.nlm.nih.gov/pubmed/21285512

Yongxing. Wang, et.al., Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation., The Journal of clinical investigation, 2011, 121

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Trp53<tm4Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5000493
• Trp53<tm4.1Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5000495

class

http://purl.org/net/cito/citesAsAuthority

• Trp53<tm4Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5000493
• Trp53<tm4.1Glo>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5000495

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• increased adenocarcinoma incidence_Trp53<tm1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0009308I129S7SvEvBrdC57BL6Trp53tm1GloTrp53tm4GloTrp53tm4GloTrp53tm1Glo
• abnormal tumor morphology_Trp53<tm1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0003448I129S7SvEvBrdC57BL6Trp53tm1GloTrp53tm4GloTrp53tm4GloTrp53tm1Glo
• increased T cell derived lymphoma incidence_Trp53<tm4Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0002024I129S7SvEvBrdC57BL6Trp53tm4GloTrp53tm4GloTrp53tm4Glo
• premature death_Trp53<tm3.1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0002083I129S7SvEvBrdC57BL6Trp53tm31GloTrp53tm4GloTrp53tm31GloTrp53tm4Glo
• increased lipoma incidence_Trp53<tm1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0010343I129S7SvEvBrdC57BL6Trp53tm1GloTrp53tm4GloTrp53tm4GloTrp53tm1Glo
• decreased body size_Mdm2<tm1Glo>/Mdm2<tm1Glo>,Trp53<tm1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0001265I129S7SvEvBrdC57BL6Mdm2tm1GloMdm2tm1GloTrp53tm1GloTrp53tm4GloTrp53tm1GloTrp53tm4GloMdm2tm1Glo
• hypoactivity_Mdm2<tm1Glo>/Mdm2<tm1Glo>,Trp53<tm1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0001402I129S7SvEvBrdC57BL6Mdm2tm1GloMdm2tm1GloTrp53tm1GloTrp53tm4GloTrp53tm1GloTrp53tm4GloMdm2tm1Glo
• increased sarcoma incidence_Trp53<tm4Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0002032I129S7SvEvBrdC57BL6Trp53tm4GloTrp53tm4GloTrp53tm4Glo
• premature death_Trp53<tm4Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0002083I129S7SvEvBrdC57BL6Trp53tm4GloTrp53tm4GloTrp53tm4Glo
• abnormal tumor morphology_Trp53<tm3.1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0003448I129S7SvEvBrdC57BL6Trp53tm31GloTrp53tm4GloTrp53tm31GloTrp53tm4Glo
• increased adenocarcinoma incidence_Trp53<tm3.1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0009308I129S7SvEvBrdC57BL6Trp53tm31GloTrp53tm4GloTrp53tm31GloTrp53tm4Glo
• altered tumor pathology_Trp53<tm3.1Glo>/Trp53<tm4Glo>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0010639I129S7SvEvBrdC57BL6CBATrp53tm31GloTrp53tm4GloTgCAGcreEsr15Amc0TgCAGcreEsr15AmcTrp53tm4GloTrp53tm31Glo
• tumor regression_Trp53<tm1Glo>/Trp53<tm4Glo>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0010537I129S7SvEvBrdC57BL6CBATrp53tm1GloTrp53tm4GloTgCAGcreEsr15Amc0TgCAGcreEsr15AmcTrp53tm1GloTrp53tm4Glo
• altered tumor pathology_Trp53<tm1Glo>/Trp53<tm4Glo>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0010639I129S7SvEvBrdC57BL6CBATrp53tm1GloTrp53tm4GloTgCAGcreEsr15Amc0TgCAGcreEsr15AmcTrp53tm1GloTrp53tm4Glo
• increased spindle cell carcinoma incidence_Trp53<tm4Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0010367I129S7SvEvBrdC57BL6Trp53tm4GloTrp53tm4GloTrp53tm4Glo
• increased sarcoma incidence_Trp53<tm1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0002032I129S7SvEvBrdC57BL6Trp53tm1GloTrp53tm4GloTrp53tm4GloTrp53tm1Glo
• increased lymphoma incidence_Trp53<tm4Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0012431I129S7SvEvBrdC57BL6Trp53tm4GloTrp53tm4GloTrp53tm4Glo
• increased adenocarcinoma incidence_Trp53<tm4Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0009308I129S7SvEvBrdC57BL6Trp53tm4GloTrp53tm4GloTrp53tm4Glo
• extended life span_Trp53<tm1Glo>/Trp53<tm4Glo>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0001661I129S7SvEvBrdC57BL6CBATrp53tm1GloTrp53tm4GloTgCAGcreEsr15Amc0TgCAGcreEsr15AmcTrp53tm1GloTrp53tm4Glo
• increased spindle cell carcinoma incidence_Trp53<tm1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0010367I129S7SvEvBrdC57BL6Trp53tm1GloTrp53tm4GloTrp53tm4GloTrp53tm1Glo
• decreased tumor growth/size_Trp53<tm3.1Glo>/Trp53<tm4Glo>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0003447I129S7SvEvBrdC57BL6CBATrp53tm31GloTrp53tm4GloTgCAGcreEsr15Amc0TgCAGcreEsr15AmcTrp53tm4GloTrp53tm31Glo
• increased lymphoma incidence_Trp53<tm3.1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0012431I129S7SvEvBrdC57BL6Trp53tm31GloTrp53tm4GloTrp53tm31GloTrp53tm4Glo
• increased spindle cell carcinoma incidence_Trp53<tm3.1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0010367I129S7SvEvBrdC57BL6Trp53tm31GloTrp53tm4GloTrp53tm31GloTrp53tm4Glo
• embryonic lethality, complete penetrance_Mdm2<tm1Glo>/Mdm2<tm1Glo>,Trp53<tm1Glo>/Trp53<tm1Glo>
  http://metadb.riken.jp/0011092I129S7SvEvBrdC57BL6Mdm2tm1GloMdm2tm1GloTrp53tm1GloTrp53tm1GloMdm2tm1GloTrp53tm1Glo
• increased sarcoma incidence_Trp53<tm3.1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0002032I129S7SvEvBrdC57BL6Trp53tm31GloTrp53tm4GloTrp53tm31GloTrp53tm4Glo
• premature death_Trp53<tm1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0002083I129S7SvEvBrdC57BL6Trp53tm1GloTrp53tm4GloTrp53tm4GloTrp53tm1Glo
• postnatal lethality, complete penetrance_Mdm2<tm1Glo>/Mdm2<tm1Glo>,Trp53<tm1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0011085I129S7SvEvBrdC57BL6Mdm2tm1GloMdm2tm1GloTrp53tm1GloTrp53tm4GloTrp53tm1GloTrp53tm4GloMdm2tm1Glo
• increased T cell derived lymphoma incidence_Trp53<tm1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0002024I129S7SvEvBrdC57BL6Trp53tm1GloTrp53tm4GloTrp53tm4GloTrp53tm1Glo
• increased lymphoma incidence_Trp53<tm1Glo>/Trp53<tm4Glo>
  http://metadb.riken.jp/0012431I129S7SvEvBrdC57BL6Trp53tm1GloTrp53tm4GloTrp53tm4GloTrp53tm1Glo
• extended life span_Trp53<tm3.1Glo>/Trp53<tm4Glo>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0001661I129S7SvEvBrdC57BL6CBATrp53tm31GloTrp53tm4GloTgCAGcreEsr15Amc0TgCAGcreEsr15AmcTrp53tm4GloTrp53tm31Glo