embryonic lethality before implantation, complete penetrance_Ppp1r15a<tm1Dron>/Ppp1r15a<tm1Dron>,Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>

http://metadb.riken.jp/0011094I129P2OlaHsd129S6SvEvTacPpp1r15atm1DronPpp1r15atm1DronPpp1r15btm1DronPpp1r15btm1DronPpp1r15atm1DronPpp1r15btm1Dron

embryonic lethality before implantation, complete penetrance_Ppp1r15a<tm1Dron>/Ppp1r15a<tm1Dron>,Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• protein phosphatase 1, regulatory (inhibitor) subunit 15b
  http://metadb.riken.jp/db/mgi_rdf/MGI:2444211
• protein phosphatase 1, regulatory (inhibitor) subunit 15A
  http://metadb.riken.jp/db/mgi_rdf/MGI:1927072

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ppp1r15a<tm1Dron>/Ppp1r15a<tm1Dron>,Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ppp1r15a<tm1Dron>|Ppp1r15b<tm1Dron>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S6/SvEvTac

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete embryonic lethality before implantation
  http://purl.obolibrary.org/obo/MP_0011094

文献

http://purl.org/net/cito/citesAsAuthority

• Heather P. Harding, et.al., Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106
  http://rdf.ncbi.nlm.nih.gov/pubmed/19181853