Heather P. Harding, et.al., Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106

http://rdf.ncbi.nlm.nih.gov/pubmed/19181853

Heather P. Harding, et.al., Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3833920

class

http://purl.org/net/cito/citesAsAuthority

• Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/db/mgi_rdf/MGI:3833920

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased birth body size_Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0009703I129P2OlaHsdPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1Dron
• decreased hematocrit_Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0000208I129P2OlaHsdPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1Dron
• decreased fetal weight_Eif2s1<tm1Rjk>/Eif2s1<+>,Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0009431I129P2OlaHsdEif2s1tm1RjkEif2s1Ppp1r15btm1DronPpp1r15btm1DronEif2s1Eif2s1tm1RjkPpp1r15btm1Dron
• decreased mean corpuscular volume_Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0002591I129P2OlaHsdPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1Dron
• abnormal liver morphology_Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0000598I129P2OlaHsdPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1Dron
• embryonic lethality before implantation, complete penetrance_Ppp1r15a<tm1Dron>/Ppp1r15a<tm1Dron>,Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0011094I129P2OlaHsd129S6SvEvTacPpp1r15atm1DronPpp1r15atm1DronPpp1r15btm1DronPpp1r15btm1DronPpp1r15atm1DronPpp1r15btm1Dron
• decreased mean corpuscular hemoglobin concentration_Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0005642I129P2OlaHsdPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1Dron
• perinatal lethality_Ppp1r15a<tm1Dron>/Ppp1r15a<+>,Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0002081I129P2OlaHsd129S6SvEvTacPpp1r15atm1DronPpp1r15aPpp1r15btm1DronPpp1r15btm1DronPpp1r15atm1DronPpp1r15btm1DronPpp1r15a
• decreased hemoglobin content_Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0002874I129P2OlaHsdPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1Dron
• decreased erythrocyte cell number_Eif2s1<tm1Rjk>/Eif2s1<tm1Rjk>,Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0002875I129P2OlaHsdEif2s1tm1RjkEif2s1tm1RjkPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1DronEif2s1tm1Rjk
• decreased erythrocyte cell number_Eif2s1<tm1Rjk>/Eif2s1<+>,Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0002875I129P2OlaHsdEif2s1tm1RjkEif2s1Ppp1r15btm1DronPpp1r15btm1DronEif2s1Eif2s1tm1RjkPpp1r15btm1Dron
• neonatal lethality, complete penetrance_Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0011087I129P2OlaHsdPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1Dron
• hypoglycemia_Eif2s1<tm1Rjk>/Eif2s1<tm1Rjk>,Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0000189I129P2OlaHsdEif2s1tm1RjkEif2s1tm1RjkPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1DronEif2s1tm1Rjk
• decreased fetal weight_Eif2s1<tm1Rjk>/Eif2s1<tm1Rjk>,Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0009431I129P2OlaHsdEif2s1tm1RjkEif2s1tm1RjkPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1DronEif2s1tm1Rjk
• neonatal lethality, complete penetrance_Eif2s1<tm1Rjk>/Eif2s1<tm1Rjk>,Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0011087I129P2OlaHsdEif2s1tm1RjkEif2s1tm1RjkPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1DronEif2s1tm1Rjk
• abnormal erythrocyte morphology_Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0002447I129P2OlaHsdPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1Dron
• pallor_Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0003717I129P2OlaHsdPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1Dron
• abnormal suckling behavior_Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0001436I129P2OlaHsdPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1Dron
• decreased erythrocyte cell number_Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0002875I129P2OlaHsdPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1Dron
• echinocytosis_Ppp1r15b<tm1Dron>/Ppp1r15b<tm1Dron>
  http://metadb.riken.jp/0000256I129P2OlaHsdPpp1r15btm1DronPpp1r15btm1DronPpp1r15btm1Dron

トランスクリプトームデータ

http://rdf.ncbi.nlm.nih.gov/pubmed/

• CD19070
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD19070
• CD22212
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD22212
• CD39228
  http://metadb.riken.jp/db/BrainTx/TranscriptomeData/CD39228