lethality throughout fetal growth and development, complete penetrance_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Parp1<tm1Zqw>/Parp1<tm1Zqw>

http://metadb.riken.jp/0011099I129S2SvPas129S6SvEvTacBrca1tm21CxdBrca1tm21CxdParp1tm1ZqwParp1tm1ZqwParp1tm1ZqwBrca1tm21Cxd

lethality throughout fetal growth and development, complete penetrance_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Parp1<tm1Zqw>/Parp1<tm1Zqw>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• breast cancer 1, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:104537
• poly (ADP-ribose) polymerase family, member 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1340806

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Parp1<tm1Zqw>/Parp1<tm1Zqw>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Parp1<tm1Zqw>|Brca1<tm2.1Cxd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S2/SvPas * 129S6/SvEvTac

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete lethality throughout fetal growth and development
  http://purl.obolibrary.org/obo/MP_0011099

文献

http://purl.org/net/cito/citesAsAuthority

• X. Wang, et.al., Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality., Cell death and differentiation, 2007, 14
  http://rdf.ncbi.nlm.nih.gov/pubmed/17318223