X. Wang, et.al., Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality., Cell death and differentiation, 2007, 14

http://rdf.ncbi.nlm.nih.gov/pubmed/17318223

X. Wang, et.al., Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality., Cell death and differentiation, 2007, 14

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• decreased cell proliferation_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Parp1<tm1Zqw>/Parp1<tm1Zqw>
  http://metadb.riken.jp/0000352I129S2SvPas129S6SvEvTacBrca1tm21CxdBrca1tm21CxdParp1tm1ZqwParp1tm1ZqwParp1tm1ZqwBrca1tm21Cxd
• lethality throughout fetal growth and development, complete penetrance_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Parp1<tm1Zqw>/Parp1<tm1Zqw>
  http://metadb.riken.jp/0011099I129S2SvPas129S6SvEvTacBrca1tm21CxdBrca1tm21CxdParp1tm1ZqwParp1tm1ZqwParp1tm1ZqwBrca1tm21Cxd
• aneuploidy_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Parp1<tm1Zqw>/Parp1<tm1Zqw>
  http://metadb.riken.jp/0004024I129S2SvPas129S6SvEvTacBrca1tm21CxdBrca1tm21CxdParp1tm1ZqwParp1tm1ZqwParp1tm1ZqwBrca1tm21Cxd
• abnormal telomere length_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Parp1<tm1Zqw>/Parp1<tm1Zqw>
  http://metadb.riken.jp/0003155I129S2SvPas129S6SvEvTacBrca1tm21CxdBrca1tm21CxdParp1tm1ZqwParp1tm1ZqwParp1tm1ZqwBrca1tm21Cxd
• abnormal cell morphology_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Parp1<tm1Zqw>/Parp1<tm1Zqw>
  http://metadb.riken.jp/0000358I129S2SvPas129S6SvEvTacBrca1tm21CxdBrca1tm21CxdParp1tm1ZqwParp1tm1ZqwParp1tm1ZqwBrca1tm21Cxd
• abnormal chromosome morphology_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Parp1<tm1Zqw>/Parp1<tm1Zqw>
  http://metadb.riken.jp/0003702I129S2SvPas129S6SvEvTacBrca1tm21CxdBrca1tm21CxdParp1tm1ZqwParp1tm1ZqwParp1tm1ZqwBrca1tm21Cxd
• decreased embryo size_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Parp1<tm1Zqw>/Parp1<tm1Zqw>
  http://metadb.riken.jp/0001698I129S2SvPas129S6SvEvTacBrca1tm21CxdBrca1tm21CxdParp1tm1ZqwParp1tm1ZqwParp1tm1ZqwBrca1tm21Cxd
• exencephaly_Brca1<tm2.1Cxd>/Brca1<tm2.1Cxd>,Parp1<tm1Zqw>/Parp1<tm1Zqw>
  http://metadb.riken.jp/0000914I129S2SvPas129S6SvEvTacBrca1tm21CxdBrca1tm21CxdParp1tm1ZqwParp1tm1ZqwParp1tm1ZqwBrca1tm21Cxd