preweaning lethality, complete penetrance_Arhgef11<tm1Sgkd>/Arhgef11<+>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>

http://metadb.riken.jp/0011100I129C57BL6JArhgef11tm1SgkdArhgef11Arhgef12tm1SgkdArhgef12tm1SgkdArhgef11Arhgef11tm1SgkdArhgef12tm1Sgkd

preweaning lethality, complete penetrance_Arhgef11<tm1Sgkd>/Arhgef11<+>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Rho guanine nucleotide exchange factor (GEF) 12
  http://metadb.riken.jp/db/mgi_rdf/MGI:1916882
• Rho guanine nucleotide exchange factor (GEF) 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:2441869

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Arhgef11<tm1Sgkd>/Arhgef11<+>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Arhgef11<+>|Arhgef11<tm1Sgkd>|Arhgef12<tm1Sgkd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete preweaning lethality
  http://purl.obolibrary.org/obo/MP_0011100

文献

http://purl.org/net/cito/citesAsAuthority

• Constantinos M. Mikelis, et.al., PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation., The Journal of biological chemistry, 2013, 288
  http://rdf.ncbi.nlm.nih.gov/pubmed/23467409