Constantinos M. Mikelis, et.al., PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation., The Journal of biological chemistry, 2013, 288

http://rdf.ncbi.nlm.nih.gov/pubmed/23467409

Constantinos M. Mikelis, et.al., PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation., The Journal of biological chemistry, 2013, 288

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5505411
• Arhgef11<tm1Sgkd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5505410

class

http://purl.org/net/cito/citesAsAuthority

• Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5505411
• Arhgef11<tm1Sgkd>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5505410

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal vascular development_Arhgef11<tm1Sgkd>/Arhgef11<tm1Sgkd>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/0000259I129C57BL6JArhgef11tm1SgkdArhgef11tm1SgkdArhgef12tm1SgkdArhgef12tm1SgkdArhgef11tm1SgkdArhgef12tm1Sgkd
• no abnormal phenotype detected_Arhgef11<tm1Sgkd>/Arhgef11<tm1Sgkd>
  http://metadb.riken.jp/0002169I129C57BL6JArhgef11tm1SgkdArhgef11tm1SgkdArhgef11tm1Sgkd
• abnormal brain vasculature morphology_Arhgef11<tm1Sgkd>/Arhgef11<tm1Sgkd>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/0004950I129C57BL6JArhgef11tm1SgkdArhgef11tm1SgkdArhgef12tm1SgkdArhgef12tm1SgkdArhgef11tm1SgkdArhgef12tm1Sgkd
• disorganized yolk sac vascular plexus_Arhgef11<tm1Sgkd>/Arhgef11<tm1Sgkd>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/0001723I129C57BL6JArhgef11tm1SgkdArhgef11tm1SgkdArhgef12tm1SgkdArhgef12tm1SgkdArhgef11tm1SgkdArhgef12tm1Sgkd
• decreased embryo size_Arhgef11<tm1Sgkd>/Arhgef11<tm1Sgkd>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/0001698I129C57BL6JArhgef11tm1SgkdArhgef11tm1SgkdArhgef12tm1SgkdArhgef12tm1SgkdArhgef11tm1SgkdArhgef12tm1Sgkd
• abnormal placental labyrinth vasculature morphology_Arhgef11<tm1Sgkd>/Arhgef11<tm1Sgkd>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/0008803I129C57BL6JArhgef11tm1SgkdArhgef11tm1SgkdArhgef12tm1SgkdArhgef12tm1SgkdArhgef11tm1SgkdArhgef12tm1Sgkd
• preweaning lethality, incomplete penetrance_Arhgef11<tm1Sgkd>/Arhgef11<tm1Sgkd>,Arhgef12<tm1Sgkd>/Arhgef12<+>
  http://metadb.riken.jp/0011110I129C57BL6JArhgef11tm1SgkdArhgef11tm1SgkdArhgef12tm1SgkdArhgef12Arhgef12tm1SgkdArhgef11tm1SgkdArhgef12
• decreased fibroblast proliferation_Arhgef11<tm1Sgkd>/Arhgef11<tm1Sgkd>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/0011704I129C57BL6JArhgef11tm1SgkdArhgef11tm1SgkdArhgef12tm1SgkdArhgef12tm1SgkdArhgef11tm1SgkdArhgef12tm1Sgkd
• abnormal embryonic erythrocyte morphology_Arhgef11<tm1Sgkd>/Arhgef11<tm1Sgkd>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/0004230I129C57BL6JArhgef11tm1SgkdArhgef11tm1SgkdArhgef12tm1SgkdArhgef12tm1SgkdArhgef11tm1SgkdArhgef12tm1Sgkd
• embryonic lethality during organogenesis, complete penetrance_Arhgef11<tm1Sgkd>/Arhgef11<tm1Sgkd>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/0011098I129C57BL6JArhgef11tm1SgkdArhgef11tm1SgkdArhgef12tm1SgkdArhgef12tm1SgkdArhgef11tm1SgkdArhgef12tm1Sgkd
• enlarged pericardium_Arhgef11<tm1Sgkd>/Arhgef11<tm1Sgkd>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/0000291I129C57BL6JArhgef11tm1SgkdArhgef11tm1SgkdArhgef12tm1SgkdArhgef12tm1SgkdArhgef11tm1SgkdArhgef12tm1Sgkd
• thin placenta labyrinth_Arhgef11<tm1Sgkd>/Arhgef11<tm1Sgkd>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/0011523I129C57BL6JArhgef11tm1SgkdArhgef11tm1SgkdArhgef12tm1SgkdArhgef12tm1SgkdArhgef11tm1SgkdArhgef12tm1Sgkd
• prenatal lethality, incomplete penetrance_Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/0011101I129C57BL6JArhgef12tm1SgkdArhgef12tm1SgkdArhgef12tm1Sgkd
• preweaning lethality, complete penetrance_Arhgef11<tm1Sgkd>/Arhgef11<+>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/0011100I129C57BL6JArhgef11tm1SgkdArhgef11Arhgef12tm1SgkdArhgef12tm1SgkdArhgef11Arhgef11tm1SgkdArhgef12tm1Sgkd
• abnormal vitelline vasculature morphology_Arhgef11<tm1Sgkd>/Arhgef11<tm1Sgkd>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/0003229I129C57BL6JArhgef11tm1SgkdArhgef11tm1SgkdArhgef12tm1SgkdArhgef12tm1SgkdArhgef11tm1SgkdArhgef12tm1Sgkd
• abnormal fibroblast proliferation_Arhgef11<tm1Sgkd>/Arhgef11<tm1Sgkd>,Arhgef12<tm1Sgkd>/Arhgef12<tm1Sgkd>
  http://metadb.riken.jp/0011702I129C57BL6JArhgef11tm1SgkdArhgef11tm1SgkdArhgef12tm1SgkdArhgef12tm1SgkdArhgef11tm1SgkdArhgef12tm1Sgkd