preweaning lethality, complete penetrance_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(EIIa-cre)C5379Lmgd/0

http://metadb.riken.jp/0011100I129S6SvEvTacFVBNPtpn11tm6BgnPtpn11TgEIIacreC5379Lmgd0Ptpn11tm6BgnPtpn11TgEIIacreC5379Lmgd

preweaning lethality, complete penetrance_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(EIIa-cre)C5379Lmgd/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• protein tyrosine phosphatase, non-receptor type 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:99511
• transgene insertion C5379, Laboratory of Mammalian Genes and Development, Heiner Westphal
  http://metadb.riken.jp/db/mgi_rdf/MGI:2137685

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(EIIa-cre)C5379Lmgd/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptpn11<tm6Bgn>|Ptpn11<+>|Tg(EIIa-cre)C5379Lmgd

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete preweaning lethality
  http://purl.obolibrary.org/obo/MP_0011100

文献

http://purl.org/net/cito/citesAsAuthority

• Gordon. Chan, et.al., Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis., Blood, 2009, 113
  http://rdf.ncbi.nlm.nih.gov/pubmed/19179468