Gordon. Chan, et.al., Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis., Blood, 2009, 113

http://rdf.ncbi.nlm.nih.gov/pubmed/19179468

Gordon. Chan, et.al., Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis., Blood, 2009, 113

pubmed

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal leukopoiesis_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0005460I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgCAGcreEsr15Amc0Ptpn11tm6BgnTgCAGcreEsr15AmcPtpn11
• increased leukocyte cell number_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000218I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• extramedullary hematopoiesis_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000240I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• preweaning lethality, complete penetrance_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(EIIa-cre)C5379Lmgd/0
  http://metadb.riken.jp/0011100I129S6SvEvTacFVBNPtpn11tm6BgnPtpn11TgEIIacreC5379Lmgd0Ptpn11tm6BgnPtpn11TgEIIacreC5379Lmgd
• abnormal liver sinusoid morphology_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008989I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• abnormal definitive hematopoiesis_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002123I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• intermingled spleen red and white pulp_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008475I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• enlarged liver_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000599I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• abnormal splenic cell ratio_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008826I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• decreased granulocyte monocyte progenitor cell number_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0013697I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• increased granulocyte number_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000322I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• decreased hematopoietic stem cell number_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0004810I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• premature death_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0002083I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• abnormal definitive hematopoiesis_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(CAG-cre/Esr1*)5Amc/0
  http://metadb.riken.jp/0002123I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgCAGcreEsr15Amc0Ptpn11tm6BgnTgCAGcreEsr15AmcPtpn11
• decreased bone marrow cell number_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000333I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• decreased common myeloid progenitor cell number_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0008813I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• increased monocyte cell number_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000220I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• abnormal bone marrow cell number_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000172I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• enlarged spleen_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000691I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• abnormal erythropoiesis_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0000245I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• anemia_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0001577I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn
• abnormal leukopoiesis_Ptpn11<tm6Bgn>/Ptpn11<+>,Tg(Mx1-cre)1Cgn/0
  http://metadb.riken.jp/0005460I129S6SvEvTacC57BL6CBAPtpn11tm6BgnPtpn11TgMx1cre1Cgn0Ptpn11Ptpn11tm6BgnTgMx1cre1Cgn