preweaning lethality, complete penetrance_Cdkn2a<tm1.1Brn>/Cdkn2a<tm1.1Brn>,Pknox1<tm1Fbla>/Pknox1<tm1Fbla>,Trp53<tm1Tyj>/Trp53<tm1Tyj>

http://metadb.riken.jp/0011100I129Sv129P2OlaHsd129S2SvPasC57BL6Cdkn2atm11BrnCdkn2atm11BrnPknox1tm1FblaPknox1tm1FblaTrp53tm1TyjTrp53tm1TyjTrp53tm1TyjPknox1tm1FblaCdkn2atm11Brn

preweaning lethality, complete penetrance_Cdkn2a<tm1.1Brn>/Cdkn2a<tm1.1Brn>,Pknox1<tm1Fbla>/Pknox1<tm1Fbla>,Trp53<tm1Tyj>/Trp53<tm1Tyj>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cyclin-dependent kinase inhibitor 2A
  http://metadb.riken.jp/db/mgi_rdf/MGI:104738
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• Pbx/knotted 1 homeobox
  http://metadb.riken.jp/db/mgi_rdf/MGI:1201409

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdkn2a<tm1.1Brn>/Cdkn2a<tm1.1Brn>,Pknox1<tm1Fbla>/Pknox1<tm1Fbla>,Trp53<tm1Tyj>/Trp53<tm1Tyj>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Tyj>|Pknox1<tm1Fbla>|Cdkn2a<tm1.1Brn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete preweaning lethality
  http://purl.obolibrary.org/obo/MP_0011100

文献

http://purl.org/net/cito/citesAsAuthority

• Luis C. Fernandez-Diaz, et.al., The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells., Development (Cambridge, England), 2010, 137
  http://rdf.ncbi.nlm.nih.gov/pubmed/20826531