embryonic lethality during organogenesis, incomplete penetrance_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Wnt1-cre)11Rth/0

http://metadb.riken.jp/0011108I129P2OlaHsdC57BL6C57BL6JSJLSJLJPtpn11tm11WbmPtpn11tm11WbmTgWnt1cre11Rth0TgWnt1cre11RthPtpn11tm11Wbm

embryonic lethality during organogenesis, incomplete penetrance_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Wnt1-cre)11Rth/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• protein tyrosine phosphatase, non-receptor type 11
  http://metadb.riken.jp/db/mgi_rdf/MGI:99511
• transgene insertion 11, David H Rowitch
  http://metadb.riken.jp/db/mgi_rdf/MGI:2447280

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Wnt1-cre)11Rth/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Wnt1-cre)11Rth|Ptpn11<tm1.1Wbm>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL * SJL/J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• partial embryonic lethality during organogenesis
  http://purl.obolibrary.org/obo/MP_0011108

文献

http://purl.org/net/cito/citesAsAuthority

• Katja S. Grossmann, et.al., The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106
  http://rdf.ncbi.nlm.nih.gov/pubmed/19805360