Katja S. Grossmann, et.al., The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106

http://rdf.ncbi.nlm.nih.gov/pubmed/19805360

Katja S. Grossmann, et.al., The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Ptpn11<tm1.2Wbm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4365540
• Ptpn11<tm1.1Wbm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4365539

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal axon extension_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0003651I129P2OlaHsdC57BL6C57BL6JSJLSJLJPtpn11tm11WbmPtpn11tm11WbmTgWnt1cre11Rth0TgWnt1cre11RthPtpn11tm11Wbm
• abnormal sensory neuron innervation pattern_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000968I129P2OlaHsdC57BL6C57BL6JSJLSJLJPtpn11tm11WbmPtpn11tm11WbmTgWnt1cre11Rth0TgWnt1cre11RthPtpn11tm11Wbm
• decreased Schwann cell number_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0001107I129P2OlaHsdC57BL6C57BL6JSJLSJLJPtpn11tm11WbmPtpn11tm11WbmTgWnt1cre11Rth0TgWnt1cre11RthPtpn11tm11Wbm
• abnormal melanocyte morphology_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0002877I129P2OlaHsdC57BL6C57BL6JSJLSJLJPtpn11tm11WbmPtpn11tm11WbmTgWnt1cre11Rth0TgWnt1cre11RthPtpn11tm11Wbm
• decreased sensory neuron number_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000966I129P2OlaHsdC57BL6C57BL6JSJLSJLJPtpn11tm11WbmPtpn11tm11WbmTgWnt1cre11Rth0TgWnt1cre11RthPtpn11tm11Wbm
• abnormal Schwann cell physiology_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>
  http://metadb.riken.jp/0011904I129P2OlaHsdC57BL6SJLPtpn11tm11WbmPtpn11tm11WbmPtpn11tm11Wbm
• embryonic lethality during organogenesis, incomplete penetrance_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0011108I129P2OlaHsdC57BL6C57BL6JSJLSJLJPtpn11tm11WbmPtpn11tm11WbmTgWnt1cre11Rth0TgWnt1cre11RthPtpn11tm11Wbm
• decreased motor neuron number_Egr2<tm2(cre)Pch>/Egr2<+>,Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>
  http://metadb.riken.jp/0000939I129P2OlaHsd129S2SvPasC57BL6SJLEgr2tm2crePchEgr2Ptpn11tm11WbmPtpn11tm11WbmPtpn11tm11WbmEgr2tm2crePchEgr2
• decreased Schwann cell precursor number_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0004075I129P2OlaHsdC57BL6C57BL6JSJLSJLJPtpn11tm11WbmPtpn11tm11WbmTgWnt1cre11Rth0TgWnt1cre11RthPtpn11tm11Wbm
• decreased nerve conduction velocity_Egr2<tm2(cre)Pch>/Egr2<+>,Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>
  http://metadb.riken.jp/0008814I129P2OlaHsd129S2SvPasC57BL6SJLEgr2tm2crePchEgr2Ptpn11tm11WbmPtpn11tm11WbmPtpn11tm11WbmEgr2tm2crePchEgr2
• abnormal myelination_Egr2<tm2(cre)Pch>/Egr2<+>,Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>
  http://metadb.riken.jp/0000920I129P2OlaHsd129S2SvPasC57BL6SJLEgr2tm2crePchEgr2Ptpn11tm11WbmPtpn11tm11WbmPtpn11tm11WbmEgr2tm2crePchEgr2
• absent Schwann cell precursors_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0001109I129P2OlaHsdC57BL6C57BL6JSJLSJLJPtpn11tm11WbmPtpn11tm11WbmTgWnt1cre11Rth0TgWnt1cre11RthPtpn11tm11Wbm
• decreased enteric neural crest cell number_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0013002I129P2OlaHsdC57BL6C57BL6JSJLSJLJPtpn11tm11WbmPtpn11tm11WbmTgWnt1cre11Rth0TgWnt1cre11RthPtpn11tm11Wbm
• abnormal craniofacial morphology_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0000428I129P2OlaHsdC57BL6C57BL6JSJLSJLJPtpn11tm11WbmPtpn11tm11WbmTgWnt1cre11Rth0TgWnt1cre11RthPtpn11tm11Wbm
• abnormal axon fasciculation_Ptpn11<tm1.1Wbm>/Ptpn11<tm1.1Wbm>,Tg(Wnt1-cre)11Rth/0
  http://metadb.riken.jp/0009450I129P2OlaHsdC57BL6C57BL6JSJLSJLJPtpn11tm11WbmPtpn11tm11WbmTgWnt1cre11Rth0TgWnt1cre11RthPtpn11tm11Wbm

class

http://purl.org/net/cito/citesAsAuthority

• Ptpn11<tm1.2Wbm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4365540
• Ptpn11<tm1.1Wbm>
  http://metadb.riken.jp/db/mgi_rdf/MGI:4365539