lethality, complete penetrance_Prkab1<tm1Eihl>/Prkab1<tm1Eihl>,Prkab2<tm1.1Grst>/Prkab2<tm1.1Grst>

http://metadb.riken.jp/0011400IC57BL6Prkab1tm1EihlPrkab1tm1EihlPrkab2tm11GrstPrkab2tm11GrstPrkab2tm11GrstPrkab1tm1Eihl

lethality, complete penetrance_Prkab1<tm1Eihl>/Prkab1<tm1Eihl>,Prkab2<tm1.1Grst>/Prkab2<tm1.1Grst>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• protein kinase, AMP-activated, beta 1 non-catalytic subunit
  http://metadb.riken.jp/db/mgi_rdf/MGI:1336167
• protein kinase, AMP-activated, beta 2 non-catalytic subunit
  http://metadb.riken.jp/db/mgi_rdf/MGI:1336185

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Prkab1<tm1Eihl>/Prkab1<tm1Eihl>,Prkab2<tm1.1Grst>/Prkab2<tm1.1Grst>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Prkab2<tm1.1Grst>|Prkab1<tm1Eihl>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• complete lethality
  http://purl.obolibrary.org/obo/MP_0011400

文献

http://purl.org/net/cito/citesAsAuthority

• Hayley M. O'Neill, et.al., AMP-activated protein kinase (AMPK) beta1beta2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21896769