increased renal glomerulus basement membrane thickness_Lepr<db>/Lepr<db>,Rock1<tm1Leiw>/Rock1<tm1Leiw>

http://metadb.riken.jp/0011409I129S7SvEvBrdC57BLKSJFVBNLeprdbLeprdbRock1tm1LeiwRock1tm1LeiwLeprdbRock1tm1Leiw

increased renal glomerulus basement membrane thickness_Lepr<db>/Lepr<db>,Rock1<tm1Leiw>/Rock1<tm1Leiw>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• leptin receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:104993
• Rho-associated coiled-coil containing protein kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:107927

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lepr<db>/Lepr<db>,Rock1<tm1Leiw>/Rock1<tm1Leiw>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lepr<db>|Rock1<tm1Leiw>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased renal glomerulus basement membrane thickness
  http://purl.obolibrary.org/obo/MP_0011409

文献

http://purl.org/net/cito/citesAsAuthority

• Wenjian. Wang, et.al., Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells., Cell metabolism, 2012, 15
  http://rdf.ncbi.nlm.nih.gov/pubmed/22326220