Wenjian. Wang, et.al., Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells., Cell metabolism, 2012, 15

http://rdf.ncbi.nlm.nih.gov/pubmed/22326220

Wenjian. Wang, et.al., Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells., Cell metabolism, 2012, 15

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1.1(Ubc-ROCK1*)Dnsh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5316078

class

http://purl.org/net/cito/citesAsAuthority

• Gt(ROSA)26Sor<tm1.1(Ubc-ROCK1*)Dnsh>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5316078

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• podocyte foot process effacement_Gt(ROSA)26Sor<tm1.1(Ubc-ROCK1*)Dnsh>/Gt(ROSA)26Sor<+>,Tg(NPHS2-icre/ERT2)1Dnsh/0
  http://metadb.riken.jp/0008140IC57BL6GtROSA26Sortm11UbcROCK1DnshGtROSA26SorTgNPHS2icreERT21Dnsh0TgNPHS2icreERT21DnshGtROSA26Sortm11UbcROCK1DnshGtROSA26Sor
• expanded mesangial matrix_Gt(ROSA)26Sor<tm1.1(Ubc-ROCK1*)Dnsh>/Gt(ROSA)26Sor<+>,Tg(NPHS2-icre/ERT2)1Dnsh/0
  http://metadb.riken.jp/0011353IC57BL6GtROSA26Sortm11UbcROCK1DnshGtROSA26SorTgNPHS2icreERT21Dnsh0TgNPHS2icreERT21DnshGtROSA26Sortm11UbcROCK1DnshGtROSA26Sor
• increased renal glomerulus apoptosis_Lepr<db>/Lepr<db>,Rock1<tm1Leiw>/Rock1<tm1Leiw>
  http://metadb.riken.jp/0011369I129S7SvEvBrdC57BLKSJFVBNLeprdbLeprdbRock1tm1LeiwRock1tm1LeiwLeprdbRock1tm1Leiw
• albuminuria_Lepr<db>/Lepr<db>,Rock1<tm1Leiw>/Rock1<tm1Leiw>
  http://metadb.riken.jp/0002871I129S7SvEvBrdC57BLKSJFVBNLeprdbLeprdbRock1tm1LeiwRock1tm1LeiwLeprdbRock1tm1Leiw
• oxidative stress_Lepr<db>/Lepr<db>,Rock1<tm1Leiw>/Rock1<tm1Leiw>
  http://metadb.riken.jp/0003674I129S7SvEvBrdC57BLKSJFVBNLeprdbLeprdbRock1tm1LeiwRock1tm1LeiwLeprdbRock1tm1Leiw
• expanded mesangial matrix_Lepr<db>/Lepr<db>,Rock1<tm1Leiw>/Rock1<tm1Leiw>
  http://metadb.riken.jp/0011353I129S7SvEvBrdC57BLKSJFVBNLeprdbLeprdbRock1tm1LeiwRock1tm1LeiwLeprdbRock1tm1Leiw
• abnormal mitochondrial physiology_Lepr<db>/Lepr<db>,Rock1<tm1Leiw>/Rock1<tm1Leiw>
  http://metadb.riken.jp/0006036I129S7SvEvBrdC57BLKSJFVBNLeprdbLeprdbRock1tm1LeiwRock1tm1LeiwLeprdbRock1tm1Leiw
• enlarged kidney_Lepr<db>/Lepr<db>,Rock1<tm1Leiw>/Rock1<tm1Leiw>
  http://metadb.riken.jp/0003068I129S7SvEvBrdC57BLKSJFVBNLeprdbLeprdbRock1tm1LeiwRock1tm1LeiwLeprdbRock1tm1Leiw
• increased kidney weight_Lepr<db>/Lepr<db>,Rock1<tm1Leiw>/Rock1<tm1Leiw>
  http://metadb.riken.jp/0003917I129S7SvEvBrdC57BLKSJFVBNLeprdbLeprdbRock1tm1LeiwRock1tm1LeiwLeprdbRock1tm1Leiw
• hyperglycemia_Lepr<db>/Lepr<db>,Rock1<tm1Leiw>/Rock1<tm1Leiw>
  http://metadb.riken.jp/0001559I129S7SvEvBrdC57BLKSJFVBNLeprdbLeprdbRock1tm1LeiwRock1tm1LeiwLeprdbRock1tm1Leiw
• albuminuria_Gt(ROSA)26Sor<tm1.1(Ubc-ROCK1*)Dnsh>/Gt(ROSA)26Sor<+>,Tg(NPHS2-icre/ERT2)1Dnsh/0
  http://metadb.riken.jp/0002871IC57BL6GtROSA26Sortm11UbcROCK1DnshGtROSA26SorTgNPHS2icreERT21Dnsh0TgNPHS2icreERT21DnshGtROSA26Sortm11UbcROCK1DnshGtROSA26Sor
• increased renal glomerulus basement membrane thickness_Lepr<db>/Lepr<db>,Rock1<tm1Leiw>/Rock1<tm1Leiw>
  http://metadb.riken.jp/0011409I129S7SvEvBrdC57BLKSJFVBNLeprdbLeprdbRock1tm1LeiwRock1tm1LeiwLeprdbRock1tm1Leiw
• increased body size_Lepr<db>/Lepr<db>,Rock1<tm1Leiw>/Rock1<tm1Leiw>
  http://metadb.riken.jp/0001264I129S7SvEvBrdC57BLKSJFVBNLeprdbLeprdbRock1tm1LeiwRock1tm1LeiwLeprdbRock1tm1Leiw
• increased body weight_Lepr<db>/Lepr<db>,Rock1<tm1Leiw>/Rock1<tm1Leiw>
  http://metadb.riken.jp/0001260I129S7SvEvBrdC57BLKSJFVBNLeprdbLeprdbRock1tm1LeiwRock1tm1LeiwLeprdbRock1tm1Leiw
• abnormal podocyte foot process morphology_Gt(ROSA)26Sor<tm1.1(Ubc-ROCK1*)Dnsh>/Gt(ROSA)26Sor<+>,Tg(NPHS2-icre/ERT2)1Dnsh/0
  http://metadb.riken.jp/0008059IC57BL6GtROSA26Sortm11UbcROCK1DnshGtROSA26SorTgNPHS2icreERT21Dnsh0TgNPHS2icreERT21DnshGtROSA26Sortm11UbcROCK1DnshGtROSA26Sor