decreased dopaminergic neuron number_Gt(ROSA)26Sor<tm1.1(Otx2)Daac>/Gt(ROSA)26Sor<tm1.1(Otx2)Daac>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>

http://metadb.riken.jp/0011448I129P2OlaHsdC57BL6DBA2GtROSA26Sortm11Otx2DaacGtROSA26Sortm11Otx2DaacSlc6a3tm11creBkmnSlc6a3GtROSA26Sortm11Otx2DaacSlc6a3Slc6a3tm11creBkmn

decreased dopaminergic neuron number_Gt(ROSA)26Sor<tm1.1(Otx2)Daac>/Gt(ROSA)26Sor<tm1.1(Otx2)Daac>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:94862
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1.1(Otx2)Daac>/Gt(ROSA)26Sor<tm1.1(Otx2)Daac>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm1.1(Otx2)Daac>|Slc6a3<+>|Slc6a3<tm1.1(cre)Bkmn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased dopaminergic neuron number
  http://purl.obolibrary.org/obo/MP_0011448

文献

http://purl.org/net/cito/citesAsAuthority

• Michela. Di Salvio, et.al., Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP., Nature neuroscience, 2010, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/21057506