increased susceptibility to dopaminergic neuron neurotoxicity_Otx2<tm6Asim>/Otx2<tm11Asim>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>

http://metadb.riken.jp/0011451I129P2OlaHsd129S1Sv129X1SvJOtx2tm6AsimOtx2tm11AsimSlc6a3tm11creBkmnSlc6a3Slc6a3Otx2tm11AsimSlc6a3tm11creBkmnOtx2tm6Asim

increased susceptibility to dopaminergic neuron neurotoxicity_Otx2<tm6Asim>/Otx2<tm11Asim>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:94862
• orthodenticle homeobox 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:97451

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Otx2<tm6Asim>/Otx2<tm11Asim>,Slc6a3<tm1.1(cre)Bkmn>/Slc6a3<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Slc6a3<+>|Otx2<tm11Asim>|Slc6a3<tm1.1(cre)Bkmn>|Otx2<tm6Asim>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased susceptibility to dopaminergic neuron neurotoxicity
  http://purl.obolibrary.org/obo/MP_0011451

文献

http://purl.org/net/cito/citesAsAuthority

• Michela. Di Salvio, et.al., Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP., Nature neuroscience, 2010, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/21057506