increased fibroblast proliferation_Braf<tm2Cpri>/Braf<+>,Kras<tm4Tyj>/Kras<+>

http://metadb.riken.jp/0011703I129S4SvJaeC57BL6Braftm2CpriBrafKrastm4TyjKrasBrafKrastm4TyjKrasBraftm2Cpri

increased fibroblast proliferation_Braf<tm2Cpri>/Braf<+>,Kras<tm4Tyj>/Kras<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• Braf transforming gene
  http://metadb.riken.jp/db/mgi_rdf/MGI:88190

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Braf<tm2Cpri>/Braf<+>,Kras<tm4Tyj>/Kras<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Braf<+>|Kras<tm4Tyj>|Kras<+>|Braf<tm2Cpri>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased fibroblast proliferation
  http://purl.obolibrary.org/obo/MP_0011703

文献

http://purl.org/net/cito/citesAsAuthority

• Catherine. Andreadi, et.al., The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway., Genes & development, 2012, 26
  http://rdf.ncbi.nlm.nih.gov/pubmed/22892241