Catherine. Andreadi, et.al., The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway., Genes & development, 2012, 26

http://rdf.ncbi.nlm.nih.gov/pubmed/22892241

Catherine. Andreadi, et.al., The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway., Genes & development, 2012, 26

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Braf<tm2Cpri>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5440045

class

http://purl.org/net/cito/citesAsAuthority

• Braf<tm2Cpri>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5440045

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• abnormal myometrium morphology_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0008256B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• intestine polyps_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0008011B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• uterus prolapse_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0005577B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• increased fibroblast proliferation_Braf<tm2Cpri>/Braf<+>,Kras<tm4Tyj>/Kras<+>
  http://metadb.riken.jp/0011703I129S4SvJaeC57BL6Braftm2CpriBrafKrastm4TyjKrasBrafKrastm4TyjKrasBraftm2Cpri
• increased spleen weight_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0004952B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• increased lung tumor incidence_Braf<tm1Cpri>/Braf<+>
  http://metadb.riken.jp/0008014I129P2OlaHsdBraftm1CpriBrafBraftm1CpriBraf
• decreased body height_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0001255B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• long incisors_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0004831B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• increased lung adenoma incidence_Braf<tm2Cpri>/Braf<+>,Kras<tm4Tyj>/Kras<+>
  http://metadb.riken.jp/0002048I129S4SvJaeC57BL6Braftm2CpriBrafKrastm4TyjKrasBrafKrastm4TyjKrasBraftm2Cpri
• cataract_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0001304B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• enlarged myocardial fiber_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0004564B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• increased cell proliferation_Braf<tm1Cpri>/Braf<+>
  http://metadb.riken.jp/0000351I129P2OlaHsdBraftm1CpriBrafBraftm1CpriBraf
• thick ventricular wall_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0002953B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• abnormal eye morphology_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0002092B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• thick interventricular septum_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0010724B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• premature death_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0002083B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• lymphoid hyperplasia_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0000688B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• cardiac hypertrophy_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0001625B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• increased skin papilloma incidence_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0002051B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• enlarged spleen_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0000691B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• increased cell proliferation_Kras<tm4Tyj>/Kras<tm4Tyj>
  http://metadb.riken.jp/0000351B6129S4Krastm4TyjKrastm4TyjKrastm4TyjKrastm4Tyj
• decreased body weight_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0001262B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• increased intestinal adenoma incidence_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0002404B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• increased lung adenoma incidence_Braf<tm1Cpri>/Braf<+>
  http://metadb.riken.jp/0002048I129P2OlaHsdBraftm1CpriBrafBraftm1CpriBraf
• increased susceptibility to ischemic brain injury_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0003076B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• enlarged heart_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0000274B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf
• abnormal facial morphology_Braf<tm2Cpri>/Braf<+>,Tg(CMV-cre)1Cgn/0
  http://metadb.riken.jp/0003743B6CgBraftm2CpriTgCMVcre1CgnBraftm2CpriBrafTgCMVcre1Cgn0Braftm2CpriTgCMVcre1CgnBraf