increased fibroblast proliferation_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>

http://metadb.riken.jp/0011703I129S6SvEvTac129S7SvEvBrdLig4tm1FwaLig4tm1FwaTrp53tm1BrdTrp53tm1BrdLig4tm1FwaTrp53tm1Brd

increased fibroblast proliferation_Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• ligase IV, DNA, ATP-dependent
  http://metadb.riken.jp/db/mgi_rdf/MGI:1335098
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lig4<tm1Fwa>/Lig4<tm1Fwa>,Trp53<tm1Brd>/Trp53<tm1Brd>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lig4<tm1Fwa>|Trp53<tm1Brd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * 129S7/SvEvBrd

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased fibroblast proliferation
  http://purl.obolibrary.org/obo/MP_0011703

文献

http://purl.org/net/cito/citesAsAuthority

• K M. Frank, et.al., DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway., Molecular cell, 2000, 5
  http://rdf.ncbi.nlm.nih.gov/pubmed/10911993