decreased fibroblast proliferation_Mcm2<Gt(AB0178)Wtsi>/Mcm2<+>,Mcm3<Gt(RRR002)Byg>/Mcm3<+>,Mcm4<chaos3>/Mcm4<chaos3>

http://metadb.riken.jp/0011704I129P2OlaHsdC3HeBFeJC57BL6JMcm2GtAB0178WtsiMcm2Mcm3GtRRR002BygMcm3Mcm4chaos3Mcm4chaos3Mcm2Mcm4chaos3Mcm3GtRRR002BygMcm3Mcm2GtAB0178Wtsi

decreased fibroblast proliferation_Mcm2<Gt(AB0178)Wtsi>/Mcm2<+>,Mcm3<Gt(RRR002)Byg>/Mcm3<+>,Mcm4<chaos3>/Mcm4<chaos3>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• minichromosome maintenance complex component 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:103199
• minichromosome maintenance complex component 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:105380
• minichromosome maintenance complex component 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:101845

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mcm2<Gt(AB0178)Wtsi>/Mcm2<+>,Mcm3<Gt(RRR002)Byg>/Mcm3<+>,Mcm4<chaos3>/Mcm4<chaos3>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mcm2<+>|Mcm4<chaos3>|Mcm3<Gt(RRR002)Byg>|Mcm3<+>|Mcm2<Gt(AB0178)Wtsi>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased fibroblast proliferation
  http://purl.obolibrary.org/obo/MP_0011704

文献

http://purl.org/net/cito/citesAsAuthority

• Chen-Hua. Chuang, et.al., Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress., PLoS genetics, 2010, 6
  http://rdf.ncbi.nlm.nih.gov/pubmed/20838603