decreased myelin sheath thickness_Erbb3<tm3Cbm>/Erbb3<tm3Cbm>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?,Tg(Dhh-cre)1Mejr/0

http://metadb.riken.jp/0011731I129P2OlaHsdC57BL6FVBNErbb3tm3CbmErbb3tm3CbmGtROSA26Sortm8Map2k1EGFPRskyTgDhhcre1Mejr0GtROSA26Sortm8Map2k1EGFPRskyTgDhhcre1MejrErbb3tm3Cbm

decreased myelin sheath thickness_Erbb3<tm3Cbm>/Erbb3<tm3Cbm>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?,Tg(Dhh-cre)1Mejr/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• erb-b2 receptor tyrosine kinase 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:95411
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 1, Dies Meijer
  http://metadb.riken.jp/db/mgi_rdf/MGI:4359596

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Erbb3<tm3Cbm>/Erbb3<tm3Cbm>,Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>/?,Tg(Dhh-cre)1Mejr/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm8(Map2k1*,EGFP)Rsky>|Tg(Dhh-cre)1Mejr|Erbb3<tm3Cbm>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased myelin sheath thickness
  http://purl.obolibrary.org/obo/MP_0011731

文献

http://purl.org/net/cito/citesAsAuthority

• Maria E. Sheean, et.al., Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination., Genes & development, 2014, 28
  http://rdf.ncbi.nlm.nih.gov/pubmed/24493648