increased hematopoietic stem cell proliferation_Mpl<tm2.1Wsa>/Mpl<tm2.1Wsa>,Tg(Pf4-icre)Q3Rsko/0

http://metadb.riken.jp/0011902IC57BL6Mpltm21WsaMpltm21WsaTgPf4icreQ3Rsko0Mpltm21WsaTgPf4icreQ3Rsko

increased hematopoietic stem cell proliferation_Mpl<tm2.1Wsa>/Mpl<tm2.1Wsa>,Tg(Pf4-icre)Q3Rsko/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• myeloproliferative leukemia virus oncogene
  http://metadb.riken.jp/db/mgi_rdf/MGI:97076
• transgene insertion Q3, Radek C Skoda
  http://metadb.riken.jp/db/mgi_rdf/MGI:3764699

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mpl<tm2.1Wsa>/Mpl<tm2.1Wsa>,Tg(Pf4-icre)Q3Rsko/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mpl<tm2.1Wsa>|Tg(Pf4-icre)Q3Rsko

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased hematopoietic stem cell proliferation
  http://purl.obolibrary.org/obo/MP_0011902

文献

http://purl.org/net/cito/citesAsAuthority

• Ashley P. Ng, et.al., Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111
  http://rdf.ncbi.nlm.nih.gov/pubmed/24711413