Ashley P. Ng, et.al., Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111

http://rdf.ncbi.nlm.nih.gov/pubmed/24711413

Ashley P. Ng, et.al., Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation., Proceedings of the National Academy of Sciences of the United States of America, 2014, 111

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Mpl<tm2.1Wsa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5607579
• Mpl<tm2.2Wsa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5607583

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• thrombocytosis_Mpl<tm2.1Wsa>/Mpl<tm2.1Wsa>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0005505IC57BL6Mpltm21WsaMpltm21WsaTgPf4icreQ3Rsko0Mpltm21WsaTgPf4icreQ3Rsko
• increased megakaryocyte cell number_Mpl<tm2.1Wsa>/Mpl<tm2.1Wsa>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0008254IC57BL6Mpltm21WsaMpltm21WsaTgPf4icreQ3Rsko0Mpltm21WsaTgPf4icreQ3Rsko
• decreased erythroid progenitor cell number_Mpl<tm2.1Wsa>/Mpl<tm2.1Wsa>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0008973IC57BL6Mpltm21WsaMpltm21WsaTgPf4icreQ3Rsko0Mpltm21WsaTgPf4icreQ3Rsko
• abnormal megakaryocyte morphology_Mpl<tm2.1Wsa>/Mpl<tm2.1Wsa>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0002417IC57BL6Mpltm21WsaMpltm21WsaTgPf4icreQ3Rsko0Mpltm21WsaTgPf4icreQ3Rsko
• increased hematopoietic stem cell proliferation_Mpl<tm2.1Wsa>/Mpl<tm2.1Wsa>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0011902IC57BL6Mpltm21WsaMpltm21WsaTgPf4icreQ3Rsko0Mpltm21WsaTgPf4icreQ3Rsko
• enlarged spleen_Mpl<tm2.1Wsa>/Mpl<tm2.1Wsa>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0000691IC57BL6Mpltm21WsaMpltm21WsaTgPf4icreQ3Rsko0Mpltm21WsaTgPf4icreQ3Rsko
• abnormal common myeloid progenitor cell morphology_Mpl<tm2.1Wsa>/Mpl<tm2.1Wsa>,Tg(Pf4-icre)Q3Rsko/0
  http://metadb.riken.jp/0006410IC57BL6Mpltm21WsaMpltm21WsaTgPf4icreQ3Rsko0Mpltm21WsaTgPf4icreQ3Rsko
• thrombocytopenia_Mpl<tm2.2Wsa>/Mpl<tm2.2Wsa>
  http://metadb.riken.jp/0003179IBALBcJC57BL6Mpltm22WsaMpltm22WsaMpltm22Wsa

class

http://purl.org/net/cito/citesAsAuthority

• Mpl<tm2.1Wsa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5607579
• Mpl<tm2.2Wsa>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5607583