neuronal cytoplasmic inclusions_Pink1<tm1Zhzh>/Pink1<tm1Zhzh>,Slc6a3<tm4.1(tTA)Xz>/?,Tg(tetO-SNCA*A53T)E2Cai/?

http://metadb.riken.jp/0011975I129P2OlaHsd129S4SvJaeSor129S6SvEvTacC57BL6Pink1tm1ZhzhPink1tm1ZhzhSlc6a3tm41tTAXzTgtetOSNCAA53TE2CaiPink1tm1ZhzhSlc6a3tm41tTAXzTgtetOSNCAA53TE2Cai

neuronal cytoplasmic inclusions_Pink1<tm1Zhzh>/Pink1<tm1Zhzh>,Slc6a3<tm4.1(tTA)Xz>/?,Tg(tetO-SNCA*A53T)E2Cai/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• PTEN induced putative kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1916193
• solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:94862
• transgene insertion E2, Huaibin Cai
  http://metadb.riken.jp/db/mgi_rdf/MGI:4420800

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pink1<tm1Zhzh>/Pink1<tm1Zhzh>,Slc6a3<tm4.1(tTA)Xz>/?,Tg(tetO-SNCA*A53T)E2Cai/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pink1<tm1Zhzh>|Slc6a3<tm4.1(tTA)Xz>|Tg(tetO-SNCA*A53T)E2Cai

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• neuronal cytoplasmic inclusions
  http://purl.obolibrary.org/obo/MP_0011975

文献

http://purl.org/net/cito/citesAsAuthority

• Linan. Chen, et.al., A53T human α-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, 35
  http://rdf.ncbi.nlm.nih.gov/pubmed/25609609