increased granulosa cell tumor incidence_Amhr2<tm3(cre)Bhr>/Amhr2<+>,Smad1<tm2Rob>/Smad1<tm2.1Rob>,Smad5<tm1Huy>/Smad5<tm1Huy>

http://metadb.riken.jp/0012411I129P2OlaHsd129SSvEvC57BL6JAmhr2tm3creBhrAmhr2Smad1tm2RobSmad1tm21RobSmad5tm1HuySmad5tm1HuyAmhr2tm3creBhrSmad1tm2RobSmad5tm1HuyAmhr2Smad1tm21Rob

increased granulosa cell tumor incidence_Amhr2<tm3(cre)Bhr>/Amhr2<+>,Smad1<tm2Rob>/Smad1<tm2.1Rob>,Smad5<tm1Huy>/Smad5<tm1Huy>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• anti-Mullerian hormone type 2 receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:105062
• SMAD family member 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:109452
• SMAD family member 5
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328787

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Amhr2<tm3(cre)Bhr>/Amhr2<+>,Smad1<tm2Rob>/Smad1<tm2.1Rob>,Smad5<tm1Huy>/Smad5<tm1Huy>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Amhr2<tm3(cre)Bhr>|Smad1<tm2Rob>|Smad5<tm1Huy>|Amhr2<+>|Smad1<tm2.1Rob>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased granulosa cell tumor incidence
  http://purl.obolibrary.org/obo/MP_0012411

文献

http://purl.org/net/cito/citesAsAuthority

• Brooke S. Middlebrook, et.al., Smad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors., Endocrinology, 2009, 150
  http://rdf.ncbi.nlm.nih.gov/pubmed/19819941