increased granulosa cell tumor incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0

http://metadb.riken.jp/0012411I129S4SvJae129X1SvJC57BL6Ctnnb1tm1MmtCtnnb1Ptentm1HwuPtentm1HwuTgCYP19A1cre1Jri0Ptentm1HwuCtnnb1tm1MmtCtnnb1TgCYP19A1cre1Jri

increased granulosa cell tumor incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• catenin (cadherin associated protein), beta 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88276
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• transgene insertion 1, JoAnne Richards
  http://metadb.riken.jp/db/mgi_rdf/MGI:3799680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ctnnb1<tm1Mmt>/Ctnnb1<+>,Pten<tm1Hwu>/Pten<tm1Hwu>,Tg(CYP19A1-cre)1Jri/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pten<tm1Hwu>|Ctnnb1<tm1Mmt>|Ctnnb1<+>|Tg(CYP19A1-cre)1Jri

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased granulosa cell tumor incidence
  http://purl.obolibrary.org/obo/MP_0012411

文献

http://purl.org/net/cito/citesAsAuthority

• J S. Richards, et.al., Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis., Oncogene, 2012, 31
  http://rdf.ncbi.nlm.nih.gov/pubmed/21860425