increased pancreas apoptosis_Brca2<tm1Cam>/Brca2<tm1Brn>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0

http://metadb.riken.jp/0013220I129P2OlaHsd129SSvEv129S4SvJaeC57BL6FVBNBrca2tm1CamBrca2tm1BrnKrastm4TyjKrasTgPdx1cre6Tuv0Brca2tm1BrnBrca2tm1CamTgPdx1cre6TuvKrastm4TyjKras

increased pancreas apoptosis_Brca2<tm1Cam>/Brca2<tm1Brn>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• breast cancer 2, early onset
  http://metadb.riken.jp/db/mgi_rdf/MGI:109337
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• transgene insertion 6, David A Tuveson
  http://metadb.riken.jp/db/mgi_rdf/MGI:5437123

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Brca2<tm1Cam>/Brca2<tm1Brn>,Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Brca2<tm1Brn>|Brca2<tm1Cam>|Tg(Pdx1-cre)6Tuv|Kras<tm4Tyj>|Kras<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreas apoptosis
  http://purl.obolibrary.org/obo/MP_0013220

文献

http://purl.org/net/cito/citesAsAuthority

• Ferdinandos. Skoulidis, et.al., Germline Brca2 heterozygosity promotes Kras(G12D) -driven carcinogenesis in a murine model of familial pancreatic cancer., Cancer cell, 2010, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/21056012