pancreatic acinar-to-ductal metaplasia_Smad4<tm1.1Gsu>/Smad4<tm1.1Gsu>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MtTGFA)Lmb/0

http://metadb.riken.jp/0013221I129S1Sv129X1SvJCD1Smad4tm11GsuSmad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb0Smad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb

pancreatic acinar-to-ductal metaplasia_Smad4<tm1.1Gsu>/Smad4<tm1.1Gsu>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MtTGFA)Lmb/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• SMAD family member 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:894293
• pancreas specific transcription factor, 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328312
• transgene insertion, Glenn Merlino
  http://metadb.riken.jp/db/mgi_rdf/MGI:3800160

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Smad4<tm1.1Gsu>/Smad4<tm1.1Gsu>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MtTGFA)Lmb/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Smad4<tm1.1Gsu>|Ptf1a<tm1.1(cre)Cvw>|Ptf1a<+>|Tg(MtTGFA)Lmb

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * CD-1

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• pancreatic acinar-to-ductal metaplasia
  http://purl.obolibrary.org/obo/MP_0013221

文献

http://purl.org/net/cito/citesAsAuthority

• Dario. Garcia-Carracedo, et.al., Smad4 loss synergizes with TGFα overexpression in promoting pancreatic metaplasia, PanIN development, and fibrosis., PloS one, 2015, 10
  http://rdf.ncbi.nlm.nih.gov/pubmed/25803032