Dario. Garcia-Carracedo, et.al., Smad4 loss synergizes with TGFα overexpression in promoting pancreatic metaplasia, PanIN development, and fibrosis., PloS one, 2015, 10

http://rdf.ncbi.nlm.nih.gov/pubmed/25803032

Dario. Garcia-Carracedo, et.al., Smad4 loss synergizes with TGFα overexpression in promoting pancreatic metaplasia, PanIN development, and fibrosis., PloS one, 2015, 10

pubmed

allele

http://purl.org/net/cito/citesAsAuthority

• Smad4<tm1.1Gsu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5792845

表現型アノテーション

http://purl.org/net/cito/citesAsAuthority

• pancreatic acinar-to-ductal metaplasia_Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0013221ICD1TgMtTGFALmb0TgMtTGFALmb
• enlarged pancreas_Smad4<tm1.1Gsu>/Smad4<tm1.1Gsu>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0003450I129S1Sv129X1SvJCD1Smad4tm11GsuSmad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb0Smad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb
• increased pancreatic intraepithelial neoplasia incidence_Smad4<tm1.1Gsu>/Smad4<tm1.1Gsu>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0009152I129S1Sv129X1SvJCD1Smad4tm11GsuSmad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb0Smad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb
• abnormal pancreatic acinar cell morphology_Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0009146ICD1TgMtTGFALmb0TgMtTGFALmb
• abnormal pancreas morphology_Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0001944ICD1TgMtTGFALmb0TgMtTGFALmb
• abnormal pancreatic acinar cell morphology_Smad4<tm1.1Gsu>/Smad4<tm1.1Gsu>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0009146I129S1Sv129X1SvJCD1Smad4tm11GsuSmad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb0Smad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb
• pancreas fibrosis_Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0003334ICD1TgMtTGFALmb0TgMtTGFALmb
• abnormal pancreatic islet morphology_Smad4<tm1.1Gsu>/Smad4<tm1.1Gsu>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0005215I129S1Sv129X1SvJCD1Smad4tm11GsuSmad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb0Smad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb
• abnormal pancreas morphology_Smad4<tm1.1Gsu>/Smad4<tm1.1Gsu>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0001944I129S1Sv129X1SvJCD1Smad4tm11GsuSmad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb0Smad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb
• pancreas cysts_Smad4<tm1.1Gsu>/Smad4<tm1.1Gsu>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0003336I129S1Sv129X1SvJCD1Smad4tm11GsuSmad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb0Smad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb
• abnormal pancreatic duct morphology_Smad4<tm1.1Gsu>/Smad4<tm1.1Gsu>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0009143I129S1Sv129X1SvJCD1Smad4tm11GsuSmad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb0Smad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb
• dilated pancreatic duct_Smad4<tm1.1Gsu>/Smad4<tm1.1Gsu>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0009144I129S1Sv129X1SvJCD1Smad4tm11GsuSmad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb0Smad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb
• increased pancreatic intraepithelial neoplasia incidence_Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0009152ICD1TgMtTGFALmb0TgMtTGFALmb
• chronic pancreas inflammation_Smad4<tm1.1Gsu>/Smad4<tm1.1Gsu>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0003341I129S1Sv129X1SvJCD1Smad4tm11GsuSmad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb0Smad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb
• abnormal pancreatic islet morphology_Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0005215ICD1TgMtTGFALmb0TgMtTGFALmb
• pancreas fibrosis_Smad4<tm1.1Gsu>/Smad4<tm1.1Gsu>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0003334I129S1Sv129X1SvJCD1Smad4tm11GsuSmad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb0Smad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb
• pancreatic acinar-to-ductal metaplasia_Smad4<tm1.1Gsu>/Smad4<tm1.1Gsu>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MtTGFA)Lmb/0
  http://metadb.riken.jp/0013221I129S1Sv129X1SvJCD1Smad4tm11GsuSmad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb0Smad4tm11GsuPtf1atm11creCvwPtf1aTgMtTGFALmb

class

http://purl.org/net/cito/citesAsAuthority

• Smad4<tm1.1Gsu>
  http://metadb.riken.jp/db/mgi_rdf/MGI:5792845