pancreatic acinar-to-ductal metaplasia_Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa>/Gt(ROSA)26Sor<+>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

http://metadb.riken.jp/0013221I129S6SvEvTacGtROSA26Sortm2Pik3caDsaGtROSA26SorPtf1atm1creHnakPtf1aPtf1atm1creHnakPtf1aGtROSA26Sortm2Pik3caDsaGtROSA26Sor

pancreatic acinar-to-ductal metaplasia_Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa>/Gt(ROSA)26Sor<+>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• pancreas specific transcription factor, 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328312

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa>/Gt(ROSA)26Sor<+>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptf1a<tm1(cre)Hnak>|Ptf1a<+>|Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa>|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• pancreatic acinar-to-ductal metaplasia
  http://purl.obolibrary.org/obo/MP_0013221

文献

http://purl.org/net/cito/citesAsAuthority

• Stefan. Eser, et.al., Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer., Cancer cell, 2013, 23
  http://rdf.ncbi.nlm.nih.gov/pubmed/23453624