abnormal ileum crypts of Lieberkuhn morphology_Col1a1<tm1(tetO-SOX2)Mjm>/Col1a1<+>,Gt(ROSA)26Sor<tm1(tTA)Roos>/Gt(ROSA)26Sor<+>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>

http://metadb.riken.jp/0013481I129P2OlaHsd129S4SvJaeC57BL6DBA2JCol1a1tm1tetOSOX2MjmCol1a1GtROSA26Sortm1tTARoosGtROSA26SorLgr5tm1creERT2CleLgr5Lgr5tm1creERT2CleGtROSA26SorLgr5Col1a1Col1a1tm1tetOSOX2MjmGtROSA26Sortm1tTARoos

abnormal ileum crypts of Lieberkuhn morphology_Col1a1<tm1(tetO-SOX2)Mjm>/Col1a1<+>,Gt(ROSA)26Sor<tm1(tTA)Roos>/Gt(ROSA)26Sor<+>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• collagen, type I, alpha 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88467
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• leucine rich repeat containing G protein coupled receptor 5
  http://metadb.riken.jp/db/mgi_rdf/MGI:1341817

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Col1a1<tm1(tetO-SOX2)Mjm>/Col1a1<+>,Gt(ROSA)26Sor<tm1(tTA)Roos>/Gt(ROSA)26Sor<+>,Lgr5<tm1(cre/ERT2)Cle>/Lgr5<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lgr5<tm1(cre/ERT2)Cle>|Gt(ROSA)26Sor<+>|Lgr5<+>|Col1a1<+>|Col1a1<tm1(tetO-SOX2)Mjm>|Gt(ROSA)26Sor<tm1(tTA)Roos>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal ileum crypts of Lieberkuhn morphology
  http://purl.obolibrary.org/obo/MP_0013481

文献

http://purl.org/net/cito/citesAsAuthority

• Andrey N. Kuzmichev, et.al., Sox2 acts through Sox21 to regulate transcription in pluripotent and differentiated cells., Current biology : CB, 2012, 22
  http://rdf.ncbi.nlm.nih.gov/pubmed/22902753