increased embryonic tissue cell apoptosis_Topbp1<tm1.2Dsh>/Topbp1<tm1.2Dsh>

http://metadb.riken.jp/0013504I129P2OlaHsd129S4SvJaeSorC57BL6C57BL6JTopbp1tm12DshTopbp1tm12DshTopbp1tm12Dsh

increased embryonic tissue cell apoptosis_Topbp1<tm1.2Dsh>/Topbp1<tm1.2Dsh>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• topoisomerase (DNA) II binding protein 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1920018

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Topbp1<tm1.2Dsh>/Topbp1<tm1.2Dsh>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Topbp1<tm1.2Dsh>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased embryonic tissue cell apoptosis
  http://purl.obolibrary.org/obo/MP_0013504

文献

http://purl.org/net/cito/citesAsAuthority

• Yoon. Jeon, et.al., TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cells., The Journal of biological chemistry, 2011, 286
  http://rdf.ncbi.nlm.nih.gov/pubmed/21149450